OBJECTIVES: End-of-dose wearing-off is commonly experienced by Parkinson’s disease (PD) patients who have used dopaminergic therapy for several years. Although investigations of wearing-off have traditionally focused on motor fluctuations, it is increasingly recognized that non-motor symptoms also vary between periods of “ON” (when PD symptoms are minimized due to medication) and “OFF” (when PD symptoms return). This study characterizes the self-reported health status of PD patients who experienced OFF-time as compared to those who were stable. METHODS: Recruited from an online panel maintained by Knowledge Networks, adults with self-reported doctor-confirmed PD were screened, consented, and completed a cross-sectional survey. Frequency of OFF-time was measured using the Unified Parkinson’s Disease Rating Scale Part IV. Demographics, PD-specific characteristics, the 9-item Wearing-off Questionnaire (WOQ-9), the Short Form-12v2 (SF-12), and the Parkinson’s Disease Questionnaire-8 (PDQ-8) were also assessed. RESULTS: Data were available for 165 PD patients (mean age = 66.6 years; 52.7% male; mean time from diagnosis = 7.1 years). Twenty-five (15%) of the patients reported experiencing no OFF-time on a typical day and were classified as stable; the remaining 85% reported experiencing OFF-time. There were few significant differences between the two groups in terms of demographics and PD history. Compared to those experiencing OFF-time, stable patients reported fewer motor and non-motor wearing-off symptoms based on the WOQ-9 (p<0.05), as well as better health on the Physical and Mental Component Summary scores of the SF-12 (p<0.05) and the Summary Index score of the PDQ-8 (p<0.01). CONCLUSIONS: PD patients who experienced at least some OFF-time on a typical day reported worse overall physical and mental well-being than stable patients. Furthermore, both motor and non-motor wearing-off symptoms differed between the two patient groups. Additional research to understand the consequences of OFF-time would be useful, especially as it pertains to non-motor symptoms.