OBJECTIVES: Economic analyses that take a societal perspective need to incorporate estimates of lost productivity due to premature death. Such estimates are likely to vary substantially across countries, making it a challenge to assess the value of alternative medical interventions on a global basis.  Our goal was to develop a generic, web-based software tool based on rigorous analytic methods that would enable researchers to assess the expected discounted present value of lost productivity for persons who die prematurely at various ages in selected developed and emerging nations. METHODS: An analytic model framework was developed to estimate the expected discounted present value of lost productivity due to premature mortality from a societal perspective using a human capital approach (with value attached to household work, as data permitted).  Key model inputs included life tables, labor force participation rates, wages, and discount rates.  Default input parameter values were based on each country’s national statistics, as available, or via generic “global” estimates when such data were lacking.      RESULTS: Model results were generated for 20 countries around the world, and varied substantially based on patient age at death and the economic region in which a country is located. For illustration purposes, the discounted present values of lost productivity for a person who dies at age 25-29 in the US, Brazil, and Sweden were estimated to be $US 945,162, 124,795, and 805,740, while the corresponding values for those who die at age 45-49 were 622,248, 76,976, and 480,480.  The web-based interface allows researchers to select the country of interest, modify default values, and conduct sensitivity analyses. CONCLUSIONS: This generic web-based software tool allows researchers to easily incorporate the value of lost productivity due to premature mortality into economic analyses that take a societal perspective, and provides estimates for many different developed and emerging countries.