OBJECTIVES: The objective of this study is to determine the potential differences in the economical impact for the National Health System (NHS) in Spain of using different glucometric systems for self-monitoring blood glucose (SMBG) in patients with type II diabetes mellitus (DM II).     METHODS: An economic model was built based on three information sources: 1) literature review, 2) costs databases and 3) expert opinion. Six different glucometers were analyzed according to their codification characteristics and their corresponding strips package characteristics, leading to four different system possibilities: 1) autocoded/individual strip package; 2) manually coded/individual strip package; and 3) autocoded/ collective strip package and 4) manually coded/collective strip package.  The perspective was that of the NHS.    RESULTS: With more than 2 million people suffering from DM II in Spain, we calculated the impact of glucometer miscoding relating it to cardiovascular episodes and glucose disorders occurred. Also collective strip package implied, due to shorter time of strip stability after its opening, considerable strip waste especially in those patients with low frequency of SMBG recommendation. Results show that autocoded glucometers which have individual package for strips safe €5 million (10%) versus those manually coded and having individual strip package in diabetic patients’ management to the NHS; versus those autocoded but with collective strip package, savings rise to €15 million (24%) and versus those manually coded and with collective package the amount of saving is of €22 million (31%). The one-way sensitivity analysis performed with the most relevant variables confirmed this tendency. CONCLUSIONS:   Glucometric systems not requiring patient intervention for coding and with individual strip package minimize the total cost of SMBG of type II diabetic patients in Spain.