OBJECTIVES: To validate the Spanish version of the quality of life (QoL) specific questionnaire for patients with COPD “Living with Chronic Obstructive Pulmonary Disease” (LCOPD). METHODS: Observational, prospective, multicenter study in a sample of patients with moderate/severe COPD. Data were collected at inclusion and at day 15, including the Spanish version of LCOPD (22 items, range:22 worst - 44 best) and the “gold standard” Saint George Respiratory Questionnaire (SGRQ). Additionally, socio-demographics,  clinical data and one item about self-perceived change in health status between visits were recorded. Feasibility, validity, reliability (internal consistency, test-retest) and responsiveness to change of the LCOPD Spanish version were evaluated. RESULTS: A total of 142 patients were included, 87.1% males, mean age (SD) was 67.4 (8.2) years, 52.7% with primary studies, 75% former smokers, FEV1 (%) = 48.5%, (SD= 13.3), 51.3% stage II, 37.6% stage III and 11.1% stage IV. Mean (SD) score in LCOPD was 33.0 (6.7). LCOPD questionnaire showed low levels of absent information: the mean number of items not responded per patient was <0.1, and no item accumulated more than 1 missing response. Floor and ceiling effects of LCOPD (proportion of patients accumulated in the minimum and maximum possible scores, respectively), were low (6%). LCOPD showed satisfactory levels of reliability: high internal consistency (Cronbach’s alpha= 0.94) and excellent test-retest reliability among patients who reported subjective stability in their health status (inter-class correlation coefficient= 0.92, p<0.001). Correlations between LCOPD and SGRQ global scores were very high (0.85), and correlations between LCOPD and SGRQ dimensions were moderate to high (0.60 to 0.87). Significant differences (p<0.05) in LCOPD were observed in exacerbated patients who reported an improvement, with a small to moderate effect size (0.31). CONCLUSIONS: According to preliminary results, Spanish version of LCOPD showed satisfactory psychometric properties in terms of feasibility, validity, reliability and responsiveness to change.