OBJECTIVES: PRINEO* Skin Closure System (PRINEO*) offers effective and safe wound closure compared to Standard of Care (SOC). This study evaluated health resource utilization attributable to PRINEO* vs. SOC for breast reduction in Germany and the Netherlands. METHODS: A time and motion study was conducted in one centre per country. Trained centre staff collected 10 observations in patients who underwent breast reduction (5 PRINEO* and 5 SOC). Data were collected for surgery through post-op care. Data Observation Forms were designed based on information obtained from staff interviews. Activities were observed for which differences in time and supplies between PRINEO* and SOC were expected: incision closure, dressing application, and dressing changes. RESULTS: In Germany, average time for skin layer closure was 3.47min with PRINEO* vs. 16.67min for SOC. Average wound length was 57cm vs. 54cm, respectively, translating into higher speed of closure with PRINEO* (16.50cm/min) compared to SOC (3.22cm/min). Overall time for wound closure was similar in both arms due to increased time for dermal layer closure with PRINEO* (42min). In the Netherlands, average time for skin layer closure was 1.57min for PRINEO* vs. 15.83min for SOC. Average wound length was 48cm vs. 49cm, respectively, translating into a speed of closure with PRINEO* of 30.74cm/min compared to 3.11cm/min with SOC. Time for dermal and skin layer closure combined was lower for PRINEO* (13.47min vs. 29.93min). For dressing application and post-op dressing changes, SOC required on average 18.28min in Germany and 3.95min in the Netherlands. Additionally, the use of 1.2 PRINEO* units on average resulted in the elimination of sutures and dressings in both centres. CONCLUSIONS: In one German and Dutch centre, the use of PRINEO* lead to increased skin closure speed and avoided time and supplies associated with dressing application and changes, at the expense of an average 1.2 PRINEO* units.