OBJECTIVES: The Global Initiative for Asthma (GINA) 2006 guidelines were revised in order to provide a new classification for asthma based on disease control and to include new treatment strategies. The aim of the current study was to describe the opinion of patients, treated according to GINA 2006 guidelines, regarding their asthma control, treatment satisfaction and quality of life (QoL). METHODS: EPAGGELIA was a descriptive, cross-sectional Greek study. The study population consisted of primary care patients with moderate/severe persistent asthma for ≥6 months, treated according to new strategies, as defined by GINA 2006, for≥3 months. Data were collected during a single visit via a structured questionnaire. Moreover, participating patients completed 3 PROs. SATQ (treatment satisfaction), ACQ-5 (asthma control), and MiniAQLQ (QoL). RESULTS: 801 patients (M/F/Missing: 353/443/5, age 49.3±15.5, 65.7% smokers) were enrolled from 104 office-based physicians. 40.2% of patients reported being “very highly” satisfied, 31.9% “highly” satisfied, 15.9% “adequately” satisfied and 12% “moderately” to “not satisfied” with their treatment. Mean SATQ score was 5.4±0.9. 52.6% of patients reported an ACQ-5 ≤1.0 and 64% a score of <1.5. Mean ACQ-5 score was 1.3±1.1, whereas mean MiniAQLQ score was 5.3 ± 1.1. Good compliance (no treatment interruption within the previous 6 months) was shown in 46.1% of patients. ACQ-5, SATQ and MiniAQLQ scores in patients with no treatment interruption as compared with those in patients with any treatment interruption were 1.2 ± 1.2, 5.4 ± 0.2, 5.5 ± 0.9 vs 1.5 ± 1.1, 5.2 ± 1.0, 5.3 ± 0.9, respectively. CONCLUSIONS: Primary care asthma patients treated according to the 2006 GINA guidelines in Greece, showed a relatively satisfactory asthma control and presented with good QoL and treatment satisfaction. However, there is room for improvement regarding disease control and treatment compliance. Compliant patients demonstrated relatively better asthma control, QoL and treatment satisfaction.