OBJECTIVES: Many researches indicate that physical activity can increase well-being and quality of life, specifically the physical and psychological domains of quality of life. The purpose of this study attempts to investigate whether physical activity also has the influence on social and environmental domains of quality of life. METHODS:  A total of 432 students at National Taiwan University participated in this study. Two questionnaires concerning the physical activity and quality of life (WHOQOL-BREF) were used. Structural equation modeling was conducted to indicate any relationships between physical activity and the social or environmental domains of quality of life. RESULTS: The results showed that the two models of predicting social and environmental domains of quality of life from physical activity did not fit the real data well if the standard items of the WHOQOL-BREF were used. However, after deleting some inappropriate items from both (social and environmental) domains of quality of life, significant relationships between physical activity and the two domains of quality of life were noted respectively. CONCLUSIONS: The study expects the impact of individual physical activity to his/her social and environmental domains of quality of life. Furthermore, physical activity can enhance not only individual physical and psychological domains of quality of life but also their social and environmental domains of quality of life by deleting some inappropriate items of the WHOQOL-BREF.