OBJECTIVES: Utility, one single value of quality of life ranged from 0 to 1, is known to differ between countries and available data in French population are sparse. This study reports on the effect of different fractures sites on self-reported EQ-5D in the post-menopausal osteoporosis population. METHODS: This cross-sectional study was carried out in general population by self completion questionnaire. Eligible women were those diagnosed for osteoporosis and aged 50 years and over. Utility was assessed using the index and VAS (range: 0-100) scores of the EQ-5D. For each group, the mean EQ-5D scores are reported. Univariate analysis on EQ5D index score permitted to select covariables. As commonly used in health status studies, multivariate linear model including previous variables was performed in order to identify factors that most affected respondents' EQ-5D scores. RESULTS: Questionnaires from a total of 637 osteoporotic women were analysed. Among them, 228 already suffered a fracture. Last osteoporotic fracture sites reported were hip (N=22), vertebrae (N=45), wrist (N=80), rib (N=65), and others (N=16). Fractured women were older (mean age: 70.3 ±8.1 vs 67.0 ±7.1 years; p<0.0001), had higher BMI values (p<0.0167) than others. When adjusted for age, the index and VAS scores of the EQ-5D were both significantly different (p<0.01) between fractured (0.72 ±0.25; 68.3 ±16.46) and non fractured women (0.77 ±0.20; 72.3 ±14.82). Moreover, patient’s utility significantly decreased for hip and vertebral fractures with -0.114 and -0.102, respectively (p<0.01). However, loss of utility for patient with other fractures was not significant (-0.017; p=0.41). CONCLUSIONS: Both hip and vertebral fractures showed durable loss of utility, whereas other osteoporotic sites do not. Used for cost-utility analyses, mean QALYs of fractures for French osteoporotic population could be also calculated.