OBJECTIVES: To evaluate the economic impact of the Non-Smokers Health Protection Act, implemented sApril 3rd, 2008 in terms of direct employment, wages, income and expenses in restaurants, bars and night clubs, in Mexico City.  METHODS: The main information source is the Monthly Services Survey, produced by Nacional Institute of Statistics and Geography. The monthly series begins in January 2005 and the last available observation is for March 2009. Natural logarithms of the dependent variables were constructed and  differences-in-differences models were estimated by Ordinary Least Squares (OLS) to evaluate the impact using a control group conformed by Nuevo León and Jalisco, states that had similar behaviour before the date of implementation. RESULTS: Differences-in-differences estimations with robust p-values in parenthesis for the effect of implementation in restaurants are 0.144 (0.57) for direct employment; 0.78 (0.568) for wages; -0.050 (0.277) for income and -0.174 (0.09) for expenses. In the case of bars and night clubs: -0.004 (.976), 0.019 (0.883), 0.025 (0.56) and -0.049 (0.552) for direct employment, wages, income and expenses, respectively. Coefficients are non significant statistically. CONCLUSIONS: With available data, we conclude that there is no statistical evidence at 95% confidence level that suggests that the implementation of the Mexico City’s Non-Smokers Health Protection Act has had a negative economic effect in direct employment, wages, income and expenses in restaurants, bars and night clubs in Mexico City.