OBJECTIVES: To assess the psychometric performance of the Children’s Dermatology Quality of Life Index (CDQoL) in Turkish pediatric dermatology  patients. The CDQoL is a specific quality of life index and which measures the impact of dermatology symptoms on QoL.  Methods. The health-related quality of life (HRQoL) is measured in a sample of 90 patients with dermatological problem using both the Turkish version of the CDQoL and the Short Form 10 (SF-10) instruments. Results. The internal consistency within the domains of the CDQoL was good, with Cronbach's Alpha values 0.78 for the CDQoL and 0.91 for the SF-10. Significant correlations were observed between the total scores of the CDQoL and the SF-10. Conclusions. Overall, the results indicated that the psychometric performance of the CDQoL in the study sample was quite good and the instrument was found to be valid and reliable. The instrument is likely to be suitable for use in clinical studies of chronic dermatological diseases in Turkey.