OBJECTIVES: To assess the estimated prevalence of fibromyalgia syndrome (FM) among the adult population in the general population, in Germany, using the London Fibromyalgia Epidemiology Study – Screening Questionnaire (LFESSQ) and American College of Rheumatology (ACR) classification criteria, METHODS: Every patients going to visit the rheumatologist in Munchen hospital during a 30-days period, were interviewed using the validated LFESSQ (4 items) with two additional questions on fatigue (LFESSQ 6 items), and examined to confirm the diagnostic of FM using ACR classification criteria. The screening questionnaire was also administered to a representative community sample more than 15 years old, selected by the quota method. The prevalence of FM was estimated in the general population, applying the predictive positive value observed in rheumatology consultation, to the positive screens, RESULTS: A total of 52.6% patients interviewed in the rheumatology department were screened positive for chronic widespread pain (LFESSQ 4), 42.7% for widespread pain and fatigue (LFESSQ 6), 16.4%[15.8-16.9] were confirmed FM cases. Based on positive screens for chronic widespread pain and LFESSQ 4, the prevalence of FM in general population, is 5.8 % (95% IC: [4.3 – 7.2] ; 7.5% in females and in 3.8% males respectively). If fatigue is added, the prevalence is 3.2 % (95% IC: [2.1 – 4.3] ; 3.9% in females and 2.5% in males respectively). Prevalence rises with age until the age group 75-84 years old. FM sufferers are females wit an average age of 53.5 years old (SD: 12.4). CONCLUSIONS: Our findings are slightly higher than those obtained in our study in France, Spain and Portugal, and those published in Canada, US or Spain, probably due to the different methodologies and populations used. Symptoms of pain as fatigue must be perceived differently according to the individuals questioned. The minimum prevalence estimated of 3.2% in Germany corresponds to 2.26 million of FM sufferers.