OBJECTIVES: CF patients need specialized long-term medication. In order to support lung function inhalable pharmaceuticals like bronchodilators, mucolytica or anti-inflammatory drugs are used. Oral or inhalable antibiotic therapy is especially important for patients whose lung has a chronic colonization with germs. In case of pancreatic insufficiency digestive enzymes have to be substituted and patients need an additional supplement of vitamins as well as high caloric food. All of these aspects lead to high medication in CF patients. Hence, aim of this work is to analyse medication mixtures and related costs for CF in Germany. METHODS: Medication data was evaluated in seven different outpatient CF centres. Data was recorded via medication lists by the physicians reporting name of medication, dosage and pharmaceutical form. As the medication is mostly a long-term regimen these resource uses were valued using biggest available packages. Prices were taken from the German “Rote Liste” with 2006 as price year. In addition, cost-influencing factors were analysed via correlation analyses. RESULTS: A total of 3150 pharmaceutical records from 301 CF patients were collected. Annual and daily medication costs were analysed for different age groups. Mean annual costs for medication are €21,603 per patient (range: €69; €86,790). Correlation analyses showed significant correlations (p=0.01) between costs of medication and age, co-morbidities (like pancreatic insufficiency and diabetes mellitus and clinical parameters like the colonization of the lung with germs) as well as functional parameters (% of vital capacity, FEV1, MEF25). E.g. mean annual costs for medication are €14,884 (€23,815) for patients without (with) colonization of the lung with germs. Other correlation factors yielded similar cost dispersions in (un)affected patients. CONCLUSIONS: CF patients need specialized medication depending on age, co-morbidities and other clinical parameters. Non-optimal treatment leads to significantly higher costs for the health care system.