OBJECTIVES: to assess the HRQoL and treatment satisfaction in diabetic patients and analyze their relationship with the glycemic control. METHODS: an epidemiological, cross sectional, naturalistic study was carried out in Spanish Primary Care centres. Patients >18 years with diabetes mellitus type 1 (T1DM) or type 2, with insulin treatment (T2DM-i) or not (T2DM-n.i), were enrolled in the study (consecutive cases sampling). The last value of glycosylated hemoglobin (HbA1c) of each patient, reported in 2006, defined the glycemic control as satisfactory (HbA1c ≤ 7%) or unsatisfactory (HbA1c>7%). HRQoL was obtained from EQ-5D questionnaire and its VAS subscale and TS from the Diabetes Treatment Satisfaction Questionnaire (SATQ-s). Differences between groups were determined by Chi-Square and t-student tests and ANCOVA models. RESULTS: A total of 679 patients were enrolled in the study: 52.4% female; age 65.2 (13.7); BMI 28.81 (4.66); type of diabetes: 11.5% T1DM, 26.2% T2DM-i and 62.3% T2DM-n.i; mean time from diagnoses 11.9 (9.25) years. 53% of patients achieved satisfactory control (T1DM: 29.5%, T2DM-i: 31.5% and T2DM-n.i: 63.8%; p<0.001). EQ-5D score were 0.76 (0.22); T1DM group obtained a little higher score, 0.86 (0.18), than T2DM groups (p<0.05) and no differences were found between glycemic control groups. VAS total score was 64.48 (17.93); patients with satisfactory control obtained a higher score, 65.72 (17.72) vs 63.30 (18.22); p<0.05. T1DM and T2DM-n.i groups reported a VAS score higher than T2DM-i: 66.41 (17.90) vs. 66.28 (17.33) vs 59.47 (18.48) respectively. SATQ-s total score was 25.01 (6.67); T2DM-n.i group was more treatment-satisfied than T2DM-i and T1DM: 26.15 (5.85) vs 22.97 (7.63) and 23.47 (7.10) respectively. Satisfactory control group also obtained a higher score than unsatisfactory control group: 25.79±6.28 vs 24.39±6.88; p<0.05. CONCLUSIONS: Patients with satisfactory glycemic control obtained better values of HRQoL (VAS) and TS. T1DM and T2DM-n.i reported better values of HRQoL and T2DM-n.i better TS.