OBJECTIVES: Normative data were collected for the Quality of Life Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA) questionnaire in the French general population in order to improve the QoL-AGHDA scoring system and its interpretability, as well as prepare for health economic assessment. METHODS: A postal survey was conducted on a sample of 2,900 adults belonging to TNS-Healthcare permanent polling panel and selected to be representative of the French population. Participants were asked to complete an 8-page questionnaire including the QoL-AGHDA questionnaire, the EuroQoL-5 Dimension (EQ-5D), a 5-point Likert scale for the participants to rate their overall health status (OHS) and questions about their general and medical situation. Socio-demographic data came from the permanent polling panel. A total score was calculated on the 25 dichotomous items of the QoL-AGHDA questionnaire, with a lower score indicating a better QoL. The description of the QoL-AGHDA score was performed on weighted data in order to ensure that the respondent population was representative of the French population. The QoL-AGHDA score was described according to OHS of respondents. Pearson correlation coefficient with the EQ-5D index was calculated. RESULTS: The return rate of questionnaires was 75%; 95% of respondents completed all QoL-AGHDA items. The mean age of the population was 50.1, with 54.1% respondents female. The mean weighted QoL-AGHDA score was 5.05 for women and 4.18 for men; it was 4.37 for people aged 18-40 years, 4.63 for 40-60 and 5.02 above 60. When described according to respondents’ OHS, it was: 1.54 for excellent OHS, 2.87 for very good, 4.49 for good, 7.73 for fair and 12.30 for poor OHS. Its correlation with the EQ-5D index was –0.59. CONCLUSIONS: Reference values for the QoL-AGHDA questionnaire have been collected for the French general population, completing the QoL-AGHDA normative database already available in a number of European countries.