OBJECTIVES: Chronic Urticaria (CU) is a frequent dermatology disease that has a great impact on Health-Related Quality of Life (HRQoL). Nowadays there is no HRQoL specific questionnaire in CU in spanish population. The objective is to develop the URQoL questionnaire in Spanish patients with CU. METHODS: In order to define the main dimensions the questionnaire should cover, a literature review and a focus group with 4 dermatologist were performed. Additionally a semi-structured interview was conducted in 11 patients with CU to evaluate the impact of the disease, symptoms and treatment on HRQoL. From the content of the interviews a first pool of items were identified. Each item was subsequently rated by the dermatologist, according to clarity, frequency and importance to reduce the number of items. Remaining items were edited in a questionnaire format and administered to a sample of patients. A debriefing analysis and preliminary psychometric analysis were performed to obtain the final pilot questionnaire before the validation study. RESULTS: A total of 33 patients were enrolled in the pilot study. Mean (SD) age 48.1(14.7) year, 66.7% were woman. After qualitative reduction a 21 items questionnaire was obtained (URQoL). One of the items was reformulated and the answer option ‘not applicable’ was added in two items (one related to working activity and the other one related to sexual activity).CONCLUSIONS:URQoL is a new HRQoL questionnaire with good initial measurement properties. With the data obtained in the ongoing validation study, a Rasch analysis will be performed and the validation process will be completed with the remaining measurement properties (feasibility, validity, reliability and responsiveness to change) and with a higher number of patients.