OBJECTIVES: To develop and validate a brief generic questionnaire to assess patients´ satisfaction with pharmacological treatment in chronic diseases. METHODS: An extensive literature review was conducted to create an initial item pool of 41 questions regarding, exclusively, satisfaction with medication. Next, two physicians and two English-Spanish translators carried out item forward-backward translation into Spanish. Moreover, comprehension and importance of items (C/I) were assessed by experts´ (5 physicians, 2 nurses and 1 psychologist) and patients´ (n=30) panels leading to an initial version of 20 items. Finally, scale item reduction and validation (feasibility, reliability and validity properties) of the final SAT-Q were carried with patients from 4 Primary Health Centres. RESULTS: In total 202 patients (65.35% female) were collected and 196 patients (97.5%) completed the questionnaire correctly. Exploratory factorial analysis (FA) and item-total correlation lead to a reduced final questionnaire (13 items). Confirmatory FA (oblimin rotation) revealed 1 general domain, global satisfaction (3 items, 72.35% of variance explained, Cronbach´s α:  0.81) along with 4 specific domains (eigenvalues >1.0): side-effects (3 items, 32.49% of variance explained, Cronbach´s α: 0.76) oversights (2 items, 14.85%, Cronbach´s α: 0.71), treatment effectiveness (3 items, 13.92%, Cronbach´s α: 0.74), adherence (2 items, 10.23%, Cronbach´s α: 0.53). Overall, test-retest correlations (n= 50) were significative (p<0.001): global satisfaction (0.69), treatment effectiveness (0.63); side-effects (0.46), adherence (0.64) oversights (0.88). Correlations between domains and Physical and Mental Summary Components of SF-12 Health Survey were respectively: global satisfaction (0.39 and 0.30; p<0.001), treatment effectiveness (0.33 and 0.19 p<0.001); side-effects (0.35 and 0.35; p<0.001), adherence (0.149 and 0.17 p<0.05), oversights (0.13; -0.01 p>0.05). CONCLUSIONS: A brief questionnaire to evaluate global and specific domains related to satisfaction with medication was developed.  Further investigation is needed to test internal consistency of adherence domain and sensitivity to change of the SAT-Q.