OBJECTIVES: To inform the model conceptualization process by identifying relevant economic models of dengue vaccine used for dengue illness and applicability to the United Kingdom setting.

METHODS: A systematic review of published full economic evaluations was performed in line with the Cochrane economic perspectives and economic evidence and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework with keywords related to "economic evaluation," "Dengue," and "vaccine, utilized in the search strategy to identify articles published between 2002 and 2022. MEDLINE, Centre for Reviews and Dissemination (CRD), PubMed Central, and relevant health journals, were searched. The CHEERS recommended criteria was used to assess the quality of the identified economic evaluations.

RESULTS: Out of 376 identified articles, 11 met the inclusion criteria. None of these studies were conducted in the UK. The selected studies predominantly utilized a cost-utility analysis design; two studies also performed budget impact analyses. Both societal and public payer perspectives were considered, and the modelling approaches varied, with five studies using Markov simulation models and three utilized a combination of Decision Trees and Markov Models. Vaccine efficacy and utility data varied across studies and health consequences were measured using Disability-Adjusted Life Years (DALYs) in eight studies and Quality-Adjusted Life Years (QALYs) in three studies.

CONCLUSIONS: The variability in model structures, methodological approaches and data parameters found in this review highlights challenges in applying the findings to the UK healthcare system. However all the studies utilized a cost-utility analysis.

The absence of UK-specific data on the cost-effectiveness of Dengue vaccines was emphasized, calling attention to the need for further research focused on Dengue vaccines for UK travelers to endemic regions to prevent future epidemics, address specific uncertainties or limitations and better inform decision-makers in the UK.