The US healthcare system is changing rapidly. Horizontal consolidation within hospital, insurer, and provider industries; as well as vertical integration across industries is increasing. The role and influence of private payers in government programs, i.e., Medicare and Medicaid, is expanding. Moreover, the composition of stakeholders is changing as private equity’s positions in healthcare businesses grow and large tech companies like Amazon, Google, Apple, Uber, etc. move into healthcare. This dynamic environment presents myriad opportunities for HEOR contributions. The objective of this forum is to describe opportunities for ISPOR, its members, and the HEOR discipline to address issues of access, affordability, and quality at a healthcare system level. Given that the field of health economics, distinct from HEOR, has long focused on studying healthcare markets, financing, and policy, the session will feature American Society of Health Economists (ASHEcon) in addition to ISPOR representation. The forum will begin with the ISPOR Chief Science Officer providing context for ISPORs vision of broadening value at the healthcare system level and the forthcoming ISPOR strategic plan update. The remaining panelists will summarize US healthcare system trends and related research. Featured topics will include insurance coverage and its effect on patient access, outcomes, and provider behavior; consolidation, integration, and healthcare financing and the implications for costs and quality; and the HEOR research of interest to large health systems and large tech companies. Each panelist will identify priority research topics, discuss differences in HEOR and health economic methodological approaches to research, and discuss areas for potential collaboration between ISPOR and ASHEcon. A moderated discussion will follow where the panelists will describe their respective organizational perspectives, resources available to all researchers, and potential areas for member development. The panel will conclude with time for audience Q&A.