OBJECTIVES:

Minimal real-world data are available for agitation among patients with bipolar disorder (BPD) or schizophrenia (SCZ). This study identified the settings of care and clinical characteristics of agitation patients.

METHODS:

Patients with BPD or SCZ with ≥1 acute agitation episode (650,539 patients) were identified by ICD codes using Clarivate Real World Data between 9/3/2015-4/29/2022. Data collected included demographics, clinical characteristics, settings of care and hospital visits. Healthcare resource utilization in the multiple clinical settings were assessed using descriptive statistics and Pearson correlation.

RESULTS:

Patient management can be complex and involves a multi-disciplinary team across settings of care. There is a broad array of comorbidities (> 2), top comorbidities include depression (61% of patients), drug abuse (36%) and fluid and electrolyte disorders (33%). Patients flow through 10+ different pathways across sites of care pre-, during and post-agitation. Following agitation episodes, 41% of patients have all-cause hospital visits within 30 days. There is a positive correlation between agitation episodes and hospital readmission (0.48) and mortality risk (0.65). Better patient management and treatments are needed to improve healthcare outcomes.

CONCLUSIONS:

Clarivate Real World Data from >6-years of data from patients with agitation associated with BPD or SCZ revealed that patient management is complex with a high rate of hospital visits. Implementation of treatment protocols and better treatment options may improve patient management, while also potentially reducing risk of mortality and hospital readmission.