A Real-World Study to Evaluate the Effect of Community Pharmacy-Based Pharmaceutical Care on the Management of Mild to Moderate Adverse Events Among Cancer Patients Taking PD-1/PD-L1 in China
Author(s)
Wen Y1, Zheng X1, Hua J2, Sun Y3, Peng QM3
1Medbanks Wisdom Pharmacy (Guangzhou) Co., Ltd, Beijing, China, 2Medbanks Wisdom Pharmacy (Guangzhou) Co., Ltd, xi'an, China, 3Medbanks Wisdom Pharmacy (Guangzhou) Co., Ltd, ChongQing, China
Presentation Documents
OBJECTIVES:
To evaluate the effect on mild to moderate adverse event (AE) of an active telephone follow-up service provided by community pharmacy in a cancer population treated with PD-1/PD-L1 compared with AEs managed by hospitals.METHODS:
De-identified records of PD-1/PD-L1 purchase and follow-up service between January 1, 2019 and March 31, 2021 from 79 Medbanks Direct-to-Patient (DTP) pharmacies across the country were extracted. All patient reported AEs were screened and information about AE’s type (according to CTCAE 5.0), severity (mild, moderate and severe), manner of management (pharmacy-based care, PBC vs. hospital-based management, HBM) and outcome (improved vs. not improved) were retrieved.RESULTS:
A total of 12,102 adverse events were reported by 6661 patients, among which 65.53% were mild, followed by moderate (28.57%) and severe (5.89%). The overall improvement rates for mild, moderate and severe AE were 77.70%, 70.85% and 63.53%, respectively. Among 7931 mild AEs, the improvement rates for PBC (n=4093) and HBM (n=3838) were 77.33% and 78.09% (P=0.432). Similar outcomes were also observed in eight out of ten most common mild AEs. However, HBM showed superiority in the management of skin and subcutaneous tissue lesion (OR=1.39, P=0.014) and vascular disease (OR=5.22, P=0.004). No statistically significant differences were observed between PBC and HBM in the management of moderate AEs either as a whole (68.66% vs. 71.38%, p=0.179) or by AE types. Conclusion: Nearly two-thirds of self-reported AE in patients taking PD-1/PD-L1 patients were mild, and more than half of them were managed by DTP pharmacies during their daily practice. For the majority of mild AEs, counseling and guidance services provided by community pharmacists through active telephone follow-up can achieve similar outcome as those managed by physician in hospital.Conference/Value in Health Info
2022-05, ISPOR 2022, Washington, DC, USA
Value in Health, Volume 25, Issue 6, S1 (June 2022)
Code
HSD79
Topic
Patient-Centered Research, Study Approaches
Topic Subcategory
Electronic Medical & Health Records, Patient-reported Outcomes & Quality of Life Outcomes
Disease
Oncology