OBJECTIVES : To study and assess the Adverse drug reaction (ADR) related hospital admissions in a tertiary care hospital.

METHODS : This prospective observational study was conducted over six months in a tertiary care hospital. Patients of any age and gender who were admitted to General Medicine, Emergency, Nephrology, Psychiatry, Pulmonology wards due to ADR were enrolled in the study. All the necessary data pertaining to ADRs were collected for assessing causality, severity, preventability and predictability and predisposing factors for ADR related hospital admissions.

RESULTS : Out of 14395 admissions to the hospital during this period, 85 admissions were identified to be caused by ADRs. Among ADR related hospital admissions, maximum admissions were seen in medicine department (50 cases). 37 males (43.52%) and 48 females (56.47%) were admitted due to ADRs. The age >61 was a risk factor for ADR related hospital admissions. As per WHO causality assessment scale and Naranjo scale, majority of the ADRs that resulted in hospital admission were deemed probable (81.17%) and 18.82% admissions possible. 72% of ADR related hospital admissions were moderate and 28% were severe.55.29% of ADR related hospital admissions were found to be predictable and 44.7% were not predictable. Among the 85 ADR related hospital admissions,9.47% were definitely preventable ,35.29% were probably preventable and 55.29% were not preventable. Long term use of the drug (16.47%) was the most common predisposing factor for developing ADR which resulted in hospital admission. Other predisposing factors identified were multiple drug therapy (12.99%).

CONCLUSIONS : The prevalence of ADR related hospital admissions was found to be 0.6%.