Association of Osteoarthritis to Incident Cancer among Adults in the United States
Author(s)
Shaikh NF1, Ikram M2, Sambamoorthi U3
1West Virginia University, School of Pharmacy, Morgantown, WV, USA, 2West Virginia University, Morgantown, WV, USA, 3University of North Texas Health Science Center, Morgantown, WV, USA
OBJECTIVES : Cancer and Osteoarthritis (OA) share common risk factors such as age, obesity, inflammation, and psychosocial factors. However, little is known about the relationship between OA and cancer. We examined the association of OA to incident cancer among non-institutionalized civilian adults in the United States. METHODS : A retrospective cross-sectional analysis of adults with OA (N= 3,362) and without OA (N=17,184) using data from 2017 Medical Expenditure Panel Survey (MEPS) was conducted. Incident cancer was identified from cancer self-administered supplement. Adjusted association was assessed using multivariable logistic regression after controlling for biological, socio-economic, access to healthcare services, medical conditions and treatment, behavioral, and environmental factors that may affect the relationship of OA to incident cancer. All analyses accounted for the complex survey design of MEPS. RESULTS : A higher percentage of adults with OA reported incident cancer compared to those without OA (7.0% vs 2.6%, p<0.001). In the unadjusted model, adults with OA had significantly higher odds of incident cancer (OR = 2.75; 95%CI = [2.25, 3.37], p<0.001) as compared to adults without OA. In the adjusted logistic regression model, with controls for age, sex, race, and chronic health conditions, adults with OA were as likely to have incident cancer as those without OA (AOR = 1.16; 95%CI = [0.94, 1.42], p=0.168). CONCLUSIONS : We did not observe a statistically significant association of OA to incident cancer after controlling for biological and clinical factors. Future studies need to explore whether the association of OA to incident cancer differ by specific types of cancer.
Conference/Value in Health Info
2021-05, ISPOR 2021, Montreal, Canada
Value in Health, Volume 24, Issue 5, S1 (May 2021)
Code
PMU27
Topic
Epidemiology & Public Health, Methodological & Statistical Research
Topic Subcategory
Public Health, Survey Methods
Disease
Multiple Diseases, Musculoskeletal Disorders, Oncology