FACTORS ASSOCIATED WITH THE FORMATION OF INHIBITORS IN PATIENTS WITH HEMOPHILIA OF THE SUBSIDIZED REGIME IN COLOMBIA.
Author(s)
Marrugo A. C1, Noriega N1, Elles R1, Fontalvo R1, Florez Tanus A2, Alvis-Guzman N3
1Fundovida IPS, Cartagena, Colombia, 2Universidad de Cartagena., Cartagena de Indias, Colombia, 3ALZAK Foundation, Universidad de la Costa, Barranquilla - Colombia, Cartagena, BOL, Colombia
OBJECTIVES : To determine the factors associated with the formation of inhibitors in patients with hemophilia of the subsidized regime in Colombia. METHODS : Retrospective, cross-sectional, descriptive and analytical study based on the database of characterization and provision of health services of a health care center specialized in the care of hematological diseases. A binomial logistic model was estimated taking as a dependent variable the formation of inhibitors in a sample of 112 patients. RESULTS : 85.71% (96) of the patients suffer from type A hemophilia. Regarding the severity of the disease, the distribution of the patients included in the study was 15 mild (13.39%), 17 moderate (15.18 %) and 80 severe (71.43%). 29.46% (33) of the patients have arthropathies. Regarding the determinants, the dose, the number of applications per week, the black race and the increase in the days of initiation of treatment in relation to the diagnosis maintain a direct relationship with the formation of inhibitors. The age measured in years becomes a protective factor, finally the presence of arthropathies and the type of hemophilia were variables that showed no statistically significant relationship in the formation of inhibitors CONCLUSIONS The formation of inhibitors is highly dose-related, the number of weekly applications, being black increases the probability of forming inhibitors. The strategy of reducing the number of days between diagnosis and the start of treatment would play a fundamental role in the appearance of inhibitors. Finally, the evidence shows that the appearance of inhibitors in adults is lower than in infants.
Conference/Value in Health Info
2020-05, ISPOR 2020, Orlando, FL, USA
Value in Health, Volume 23, Issue 5, S1 (May 2020)
Code
PRO40
Topic
Epidemiology & Public Health, Methodological & Statistical Research
Disease
Rare and Orphan Diseases