OBJECTIVES: Studies suggest that users of beta‐blockers reported less pain and were less likely to use opioids and other analgesics compared to non-users of beta-blockers. The association of beta-blockers to chronic pain is an under-researched area. This study examined the independent association of beta-blocker use to severe pain among adults with CVDs or hypertension. METHODS: We adopted a cross-sectional study design. We used data on 8,168 adults from 2015 Medical Expenditure Panel Survey (MEPS). Study participants were adults (age ≥ 21 years), with hypertension or CVDs. Chronic pain was derived from SF-12 item that queried that respondents about pain interference with normal activities. We used “severe or extreme pain” that interfered with normal work in 4 weeks prior to the interview as a proxy for chronic pain. We performed multivariable survey logistic regressions to examine the independent association of beta-blockers to chronic pain. These regressions controlled for demographic, socio-economic status, access to healthcare, and lifestyle practices. All analyses accounted for the complex survey design of the MEPS. RESULTS: In our study, 24.1%, 42.0%, and 33.9% reported using beta-blockers, other antihypertensives, and no antihypertensive medications, respectively; among adults using beta-blockers 22.2% reported chronic pain; among those without any antihypertensive medications, the prevalence of chronic pain was 11.8%. In unadjusted model, beta-blocker use was associated with chronic pain (UOR= 2.13, 95%CI= 1.77-2.57). In fully adjusted models, beta-blocker use was no longer statistically significant (AOR= 1.24, 95%CI= 0.99-1.55). CONCLUSIONS: In this first population-based study, we observed that beta-blockers use was not associated with chronic pain in adults with CVDs or hypertension. Prospective cohort studies are needed to provide robust evidence on the association of beta-blockers to chronic pain.