PREDICTORS OF HEALTH-RELATED QUALITY OF LIFE DECLINE IN INTERSTITIAL LUNG DISEASE USING THE K-BILD QUESTIONNAIRE

Author(s)

Maqhuzu PN1, Szentes B2, Kreuter M3, Bahmer T4, Kahn NC3, Claussen M4, Holle R5, Schwarzkopf L2
1Helmholtz Zentrum Munchen, Neuherberg, BY, Germany, 2Helmholtz Zentrum Munchen, Neuherberg, Germany, 3Heidelberg University Hospital, Heidelberg, Germany, 4LungenClinic Grosshansdorf, Großhansdorf, Germany, 5Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany

OBJECTIVES : Health-related quality of life (HRQL) in patients with interstitial lung disease (ILD) is impaired; however, predictors for HRQL decline over time are rarely examined. We aimed to identify predictors for HRQL decline in ILD-patients within a 12-months observation period.

METHODS

We used longitudinal data of 194 ILD patients recruited at two large German ILD centers in the observational HILDA study. We applied EQ-5D-VAS and the disease-specific King’s Brief Interstitial Lung Disease questionnaire (KBILD) with the subdomains ‘psychological impact’, ‘chest symptoms’ and ‘breathlessness and activities’. Scores for the measures ranged between zero (worst HRQL) and 100 (best HRQL). We analyzed the proportion of patients who experienced a clinically meaningful decline in HRQL using minimal clinically important differences, and investigated various patient characteristics as potential predictors of HRQL deterioration.

RESULTS

Within the study population (34.0% male, Ø age 61.7) mean HRQL scores hardly changed between baseline and 12-months follow-up (K-BILD total score: 52.8 vs. 52.5 | VAS: 60.0 vs. 57.3). On the intra-individual level, 29.4% (n = 57) of patients experienced clinically relevant deterioration in 'breathlessness and activities’, 29.9% (n = 58) in ‘chest symptoms’ and 28.4% (n = 55) in ‘psychological impact’. 30.4% (n = 59) deteriorated according to K-BILD total score and 35.4% (n = 68) in VAS.

Lower baseline DLCO% predicted was associated with HRQL deterioration in ‘breathlessness and activities’ (ß– coefficient-0.04, p = 0.003) and ‘chest symptoms’ (ß– coefficient -0.04, p = 0.002) while baseline FVC% predicted deterioration in ‘psychological impact’ (ß– coefficient -0.02, p = 0.014), KBILD total score (ß– coefficient -0.02, p = 0.007) and VAS (ß–coefficient -0.03, p < 0.0001). Additionally, increasing age was negatively associated with deterioration in ‘psychological impact’ (ß–coefficient 0.06, p < 0.0001).

CONCLUSIONS

A third of ILD patients experienced a clinically relevant HRQL deterioration in 12 months, mainly predicted by lung function baseline values.

Conference/Value in Health Info

2020-05, ISPOR 2020, Orlando, FL, USA

Code

PRS62

Topic

Patient-Centered Research

Topic Subcategory

Patient-reported Outcomes & Quality of Life Outcomes

Disease

Respiratory-Related Disorders

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