OBJECTIVES: To describe trends in list prices, net prices, and discounts for self-administered disease-modifying therapies (DMTs) for multiple sclerosis (MS) from 2007-2019.

METHODS: We obtained 2007-2019 pricing data for dimethyl fumarate, fingolimod, glatiramer acetate, interferon beta-1A, interferon beta-1B, peginterferon beta-1A, and teriflunomide from SSR Health, which provides quarterly estimates of list prices, net prices, and discounts in Medicaid and other payers for branded products manufactured by publicly traded companies. For each drug and year, we calculated average list and net annual costs of treatment based on FDA-approved dosing; and average discounts in Medicaid and other payers.

RESULTS: From 2007-2019, list prices of self-administered MS DMTs increased by 4.5-fold or 13.4% each year, from an annual cost of treatment of $20,862 to $93,496. Net prices increased by 3.8-fold or 12.2% each year, from an annual cost of treatment of $17,880 to $68,058. Annual increases in list and net prices were higher in 2007-2014, when they averaged 17-18%, but slowed down after 2015, with annual increases of 10.9% and 6.9% in 2015-2017. After 2017, list prices increased by an annual average of 5.9%, while net prices leveled off. From 2007-2019, manufacturer discounts for self-administered MS DMTs increased, on average, by 40.4 percentage points for Medicaid, from 26.7% to 67.1%; and by 7.2% for payers other than Medicaid, from 8.5% to 15.7%.

CONCLUSIONS: Prices of self-administered MS DMTs rose dramatically in 2007-2019, even after accounting for manufacturer discounts. Recent leveling off of net prices was particularly driven by increases in manufacturers discounts for payers other than Medicaid.