Increasingly healthcare decision makers are looking for new opportunities that can help reduce the time required to bring health innovation to patients. Real-world evidence (RWE) is currently in the spotlight, however regulators (amongst others) remain cautious as they evaluate how much they can trust RWE. We are forming a new RWE SIG dedicated to increasing awareness, understanding, rigor and utilization of RWE as an important part of the wider evidence base for healthcare decision making. In order to be successful, ISPOR needs you, its members, to support this initiative, to address known and emerging challenges so that patients ultimately get access to the right treatment, at the right time. This open SIG meeting will present a range of RWE-specific topics to ascertain which concerns require immediate action, whether ISPOR is best placed to contribute to the solution and to start defining how we collectively might address them. During the meeting, attendees will have the opportunity to contribute their perspectives, suggest alternative topics and volunteer to help advance the future activities of the SIG.