ECONOMIC EVALUATION OF OMEGA-3 FATTY ACIDS IN POSTOPERATIVE PATIENTS WITH GASTROINTESTINAL TUMORS

OBJECTIVES

: To evaluate the effect of omega-3 fatty acids interventions on the clinical outcomes of postoperative gastrointestinal cancer patients and economic analysis.

METHODS

: Searching PubMed, EMBASE, Cochrane, Web of Science, China Knowledge Network, Wanfang, and Weipu among Chinese and English databases from the database to the May 4, 2018 related research, according to the inclusion and exclusion criteria screening eligible RCT studies. The literature quality was evaluated using the quality assessment method recommended by the Cochrane system evaluator's manual. Meta analysis was performed with RevMan 5.3 software and economics evaluation was performed with a decision tree model.

RESULTS

: 21 RCTs，1293 surgical patients，were included.Meta-analysis showed that the incidence of infectious complications was lower in the omega-3 fatty acids group than in the control group, with statistical significance [RR=0.48, 95% CI (0.33, 0.68), P<0.0001; Peto OR=0.42, 95% CI (0.28) , 0.63), P<0.0001]. There was no statistical difference in mortality between the omega-3 fatty acids group and the control group. [RR=0.42, 95% CI (0.07, 2.63), P=0.36; Peto OR=0.39, 95% CI (0.05, 2.86), P=0.35]. The length of postoperative hospital stay in the omega-3 fatty acids group was shorter than that of the control group, with statistical differences [MD = -1.12, 95% CI (-1.89, -0.35), P = 0.004]. Perform cost-effectiveness analysis,△E/△C=-3608.1yuan

CONCLUSIONS

: The use of omega-3 fatty acids in postoperative patients with gastrointestinal tumors may significantly reduce the incidence of infection complications and length of hospital stay, without affecting the mortality rate but more economical.