OBJECTIVES: To characterise disease burden, clinical characteristics, treatment satisfaction and health-related quality of life (HRQoL) in people living with HIV (PLWH) who are treatment experienced (TE) or treatment naïve (TN) currently taking DTG/3TC in five European countries (France, Germany, Italy, Spain, United Kingdom).

METHODS: Data were drawn from the Adelphi HIV Disease Specific Programme, a real-world, cross-sectional survey run between September 2022 and April 2023. Physicians provided data for PLWH taking DTG/3TC, including demographics, clinical characteristics, and satisfaction with anti-retroviral therapy (ART). PLWH completed surveys voluntarily, capturing perspectives on HRQoL (HIV-specific QoL captured using PozQoL [scale 0-5]; generic HRQoL using EQ-5D [scale 0-1]), and treatment satisfaction. All analysis was descriptive.

RESULTS: PLWH currently on DTG/3TC (n=282; TN [n=110] and TE [n=172]) had been on it for approximately 18 months (mean [sd]; Overall: 17.1 [12.1]; TN: 15.3 [12.8]; TE: 18.2 [11.6] months). Almost all TE PLWH were currently virally suppressed (Overall: 86.5%; TN: 70.9%; TE: 96.5%). High levels of physician-reported adherence were seen (Overall: 94.7%; TN: 89.1%; TE 98.2% reported completely/mostly adherent). High physician-reported treatment satisfaction was seen (Overall: 96.4%; TN: 96.3%; TE: 96.5%; satisfied / very satisfied) as well as for PLWH-reported satisfaction (Overall: 86.9%; TN: 94.7%; TE: 83.3%; satisfied / very satisfied). The most commonly reported reasons for PLWH dissatisfaction (n=23) were not wanting to take daily pills (Overall: 39.1%), reminder of having HIV (Overall: 26.1%) and fear of disclosure (Overall: 21.7%). High HRQoL was seen using EQ-5D-5L (Overall [n=61]: 0.92; TN [n=19]: 0.94, TE [n=42]: 0.91) and PozQoL (Overall: 3.3; TN: 3.4; TE: 3.3).

CONCLUSIONS: Both TE and TN groups taking DTG/3TC showed high HRQoL as well as high treatment satisfaction. Taken together with previously published efficacy and safety data, DTG/3TC has a role for treating both TN and TE PLWH.