OBJECTIVES:

This study sought to estimate the prevalence of recurrent Major Adverse Cardiovascular Events (MACE) within 90 days and one year amongst patients who experienced a myocardial infarction (MI) and had evidence of Multi-vessel disease (MVD).

METHODS:

This retrospective study utilized German claims data (AOK PLUS), covering the period 01/01/2010 to 31/12/2020. Patients were included if they (i) had an inpatient diagnosis of an MI between 01/01/2012-12/31/2019 (index date), (ii) were ≥ 18 years of age, (iii) had evidence of MVD (ICD-10-GM codes I25.12, I25.13, I25.14), (iv) had diabetes, or met two of the following: ≥ 65 years old, prior MI or peripheral arterial disease. Acute kidney injury/failure, hemodynamic instability, hepatobiliary disease, severe chronic kidney disease or coronary artery bypass graft surgery (CABG) at baseline led to exclusion. MACE was defined as (i) MI, (ii) stroke or (iii) death with a previous cardiovascular (CV) diagnosis within 30 days.

RESULTS:

Based on the inclusion criteria stated above 5,158 patients were included in the analysis (average age: 74.21 years, females: 33.62%, average Charlson Comorbidities Index (CCI): 5.99). Of those, 22.06% experienced a MACE within 90 days following the index MI (average age: 76.65 years, females: 34.09%, average CCI: 6.94) and 31.17% within 1 year. Of those who had an event within 90 days (N= 1,138), 39.81% experienced a recurrent MI, 36.29% a stroke, and 23.90% a CV related death as their first recurrent MACE event. 4.92% (N=56) had a recurrent MI and a stroke within 90 days after index event.

CONCLUSIONS:

The risk of experiencing a MACE is high in the first year after an acute MI, especially in the first 90 days. Further research will be conducted to assess the risk factors and estimate the burden of disease in MI patients with evidence of MVD who experience a MACE.