OBJECTIVES:

HAS defined an organizational impact (OI) as an effect, consequence, result, repercussion created by a health technology on the characteristics and functioning of an organization or a set of organizations involved in the care of users. In 2021, HAS has published an ‘Organizational Impact Map’, to evaluate the OI of health products. As immune-checkpoint inhibitors (ICI) have considerably modified management of cancer patients, the objective is to assess OIs of ICIs in advanced cancers care in France.

METHODS:

A literature review was firstly performed to identify organizational aspects related to the availability of ICI and their related period (learning or ‘routine’ phase). All identified OIs were classified into the map and its 3 macro-criteria (MC): impact on the care process (MC1, 6 criteria), impact on the capabilities and skills required of stakeholders to implement the care process (MC2; 6 criteria) and impact on society or community (MC3; 4 criteria). In a second step, interviews with healthcare stakeholders were planned to rank the criteria and include a qualitative assessment.

RESULTS:

The literature review showed that ICI availability impacted the 3 macro criteria: OIs were observed in half MC1 criteria (n=3), for all MC2 criteria (n=6) and for a quarter of MC3 criteria (n=1). In MC1, the main OI was the extension of treatment duration, observed in both learning and routine phases. In MC2, OIs were related to stakeholder’s required skills (for adverse events management), transfer of skills and logistic constraints, mainly observed in the learning phase. In MC3, the only OI was related to inequalities in care accessibility.

Interviews with around 20-30 healthcare stakeholders (general practitioners, oncologists, organ specialists, pharmacists, nurses, medicines agencies, patients’ associations) will be presented.

CONCLUSIONS:

This preliminary work enabled to identify OIs related to ICI availability in France. Interviews with stakeholders will be helpful to validate and illustrate these results.