OBJECTIVES

The main objective of this study is to assess the morphology, causality, severity and preventability of the cutaneous adverse drug reaction in the tertiary care hospital.

METHODS

154 patients with the diagnosis of CADRs were included in the study in the duration of six months (September 2019- February 2020). The information such as patient’s demographic details, drug history and pattern of the drug reaction was noted. The Naranjo’s ADR probability scale was use for the assessment of the causality of the CADRs, modified Hartwieg and Siegel scale for the assessment of severity of the reaction and Schumock and Thornton scale for the assessment of preventability of the reaction.

RESULTS

Among 154 patients included in the studied, around 42.59 percent of the patient developed maculopapular rash, 9.25 percent developed Urticaria, around 31.48 percent developed itching, 20.37 percent developed fixed drug eruption, Toxic epidermal necrolysis (TEN) was developed in around 3.7 percent of the patient, DRESS was seen in 5.5 percent of the patients, Angioedema was also developed in 5.5 percent of the patients and redness was seen in around 12.96 percent of the patients. From this study, maculopapular rash was the most occurring cutaneous adverse drug reactions

CONCLUSIONS

Cutaneous ADRs can range from mild to severe increasing the financial burden, pain and mental stress to the patient. Their knowledge is very essential for the clinicians for the early recognition or diagnosis of the Cutaneous ADRs so that it can be treated more efficiently and promptly and early withdrawal of the culprit drug can save the patient from the fatal consequences.