OBJECTIVES: The purpose of the study was to assess the consequences of introducing drug dose control into the medical information system (MIS) while adding the information of the prescribed drugs into the electronic health record by blocking the prescription when a single or daily dose is exceeded according to the instructions for use, with further doctor notification.

METHODS: Analysis and economic assessment of the several drug groups consumption were carried out using the ACT / DDD methodology before and after the introduction of a drug dose regimen monitoring into the surgical hospital MIS when adding the information of the prescribed drugs into the electronic health record. Monitoring included blocking the prescription when a single or daily dose is exceeded according to the instructions for use with further doctor notification.

RESULTS: Pharmacoepidemiological analysis showed that the excess of single and daily doses can occur in up to 15% of cases of drug prescription, which lead to a significant increase in the drug therapy cost. Based on the results of the drug consumption database statistical processing, it was determined that most violations of the dose regimen happened while prescribing antibacterial drugs, non-narcotic analgesics, and non-steroidal anti-inflammatory drugs. ACT / DDD analysis showed a significant decrease in the consumption of the indicated groups of drugs after the introduction of the dose regimen control. Economic analysis identified a reduction in the cost of drug provision.

CONCLUSIONS: The introduction of CDSS elements into the real-world clinical practice by the example of dose control leads to a decrease in the irrational consumption of drugs and to a decrease in costs. ACT/DDD methodology, together with pharmacoeconomic and epidemiological analyses are important tools for assessing drug consumption in medical institutions, allowing to evaluate the consequences of the introduction of various management technologies, including CDSS elements.