Author(s)
Alonso Caballero J1, Gabilondo A2, ROCA Bennasar MA3, Vieta E4, Hernando T5, Sicras-Mainar A6, Sicras-Navarro A7, Herrera B5, Pérez V8
1IMIM (Hospital del Mar Medical Research Institute) and CIBERESP, Madrid, M, Spain, 2Outpatient Mental Health Care Network, San Sebastian, Spain, 3Institut Universitari d' Investigació en Ciències de la Salut, Idisba, Rediapp, University of Balearic Islands, Palma de Mallorca, Spain, 4Bipolar Disorders Unit, Clinical Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain, 5Janssen, Madrid, Spain, 6HEOR Dep, Atrys Health, Barcelona., Spain, 7HEOR Dep, Atrys Health, Barcelona, B, Spain, 8Hospital del Mar, Department of Psychiatry, Institut de Neuropsiquiatria i Addiccions; IMIM (Hospital del Mar Medical Research Institute); Centro de Investigación Biomédica En Red de Salud Mental (CIBERSAM), Barcelona, Spain
OBJECTIVES. To assess frequency of depressive disorder (DD) in usual clinical practice, and to estimate the associated indirect-costs. Additionally, we estimated the population costs of DD in Spain. METHODS. A retrospective, observational-study was carried out using the BIGPAC-database® (http://www.encepp.eu/encepp/viewResource.htm?id=29236). Study-population: patients aged ≥ 18 years diagnosed with DD in 2015-2017. The prevalence was determined as the total diagnosed cases of DD in the adult general population. The incidence rate was calculated as the number of new cases of DD diagnosed per 1,000 person-years in the population attended (2015-2017). We collected demographic variables, comorbidity, and costs: direct and indirect-costs (temporary and permanent disability). Healthcare direct costs associated with DD were estimated according to the annual resources use rate (resources/patient/year). Indirect-costs were calculated according to the human capital method. Using the study data and information from the National Statistical Institute (INE-Spain), we estimated the cost of DD relative to the Spanish adult population, including premature mortality. RESULTS. 69,217 patients aged ≥ 18 years who met the study inclusion/exclusion criteria were analyzed (mean age: 56.8years; female: 71.4%; deaths: 2.2%). The prevalence of DD in the general population was 4.73% (95% CI:4.70-4.76). The incidence rates were 7.12, 7.35 and 8.02 per 1,000 person-years for 2015, 2016 and 2017 respectively. The overall total costs (direct costs plus indirect ones) were € 223.9 million (69,217 patients x € 3,235.3; mean/patient/year): 18,4% direct costs and 81.6% indirect-costs (temporary occupational disability: 18%; permanent disability: 63.6%). The cost of DD in the Spanish adult population was estimated at € 6,145 million. Mean cost per patient/year was € 3,402, being the mean cost per inhabitant/year € 161. CONCLUSIONS. Prevalence and incidence of DD in Spain are similar to other series reviewed. Overall total costs related to DD were high, being the indirect-costs the main driver of the economic burden associated to DD.
Conference/Value in Health Info
2020-11, ISPOR Europe 2020, Milan, Italy
Value in Health, Volume 23, Issue S2 (December 2020)
Code
PMH10
Topic
Economic Evaluation, Epidemiology & Public Health
Topic Subcategory
Work & Home Productivity - Indirect Costs
Disease
Mental Health
