Can Blood Units Coming from Whole Blood Automation Deliver a Clinically Meaningful Difference to Anemic Patients Versus Alternative Blood Collection Types?
Author(s)
Pérez Aliaga AI1, Cardoso M2, Comasolivas N2, Dierick K3
1Blood Bank and Tissues of Aragón, Zaragoza, Spain, 2Terumo BCT, Zaventem, Belgium, 3Terumo BCT Europe NV, Zavemtem, Belgium
OBJECTIVES With COVID-19 voluntary blood donations strongly reduced, clinicians are investigating which whole blood types or red blood cells concentrates (RBC) deliver most clinical value at the lowest volume possible. Hence the objective of this research was to investigate if the type of whole blood process could drive clinically meaningful differences for severely anemic patients. METHODS By means of literature review we investigated the main drivers of clinical outcomes in severe anemia (i.e. circulating blood volume and hemoglobin level (Hb)). Next we created different patient scenarios in severity of anemia and hence the need for blood transfusion. After this we compared the characteristics of blood units (volume and hemoglobin concentration) coming from whole blood automation (WBA) versus those coming from manual or semi-automated whole blood processes (mBC). Next we evaluated how these characteristics may deliver value to patients and their professional caregivers. RESULTS We found that between 5% and 35% of blood loss, as many WBA-derived RBC and mBC-derived units would need to be transfused to patients to overcome the anemia. Between 35% and 75% blood loss WBA-derived RBC requires on average 33% less blood units to restore normal volume and Hb concentration levels than mBC-derived RBC. CONCLUSIONS In times of blood shortage, patients suffering from severe, acute bleeding and reduced Hb levels are likely to benefit faster from WBA-derived RBC transfusion blood units to improve oxygen delivery to cells than from mBC-derived RBC.
Conference/Value in Health Info
2020-11, ISPOR Europe 2020, Milan, Italy
Value in Health, Volume 23, Issue S2 (December 2020)
Code
PMD11
Topic
Economic Evaluation, Health Service Delivery & Process of Care
Topic Subcategory
Cost-comparison, Effectiveness, Utility, Benefit Analysis, Hospital and Clinical Practices
Disease
Injury and Trauma, Medical Devices