OBJECTIVES

: To conduct a systematic review of the literature on the clinical efficacy of the Thrombodynamics Analyser System (TD) for the evaluation of the coagulation state of the blood.

METHODS : We searched Medline, the Cochrane Library, and Russian database eLIBRARY for clinical studies reported comparative efficacy of TD as an additional test to other methods for evaluating the hemostasis system. The search was conducted in April 2019 and included studies published in English or Russian.

RESULTS

: 363 citations were found (104 in Medline and the Cochrane Library, 132 references in eLIBRARY and 127 publications in references), of which six relevant publications were included. Five studies evaluated the effectiveness of TD for assessing the risk of venous thromboembolic complications (VTEC) and one study assessed the effectiveness of TD for predicting the success of in vitro fertilization (IVF) procedures. Initial clot growth rate (Vi, µm / min) (Lobastov K. et al., 2020; Katelnitskaya O.V. et al., 2017), the stationary clot growth rate (Vs, µm / min) (Lobastov K. et al., 2020), the appearance of spontaneous clots (SC, %) Katelnitskaya O.V. et al. (2017), the clot growth rate (V, µm / min) (Silina et al., 2016), the measurement results of TD, were predictor markers of VTEC in the postoperative period. The clot growth rate (V, µm / min) > 32.3 μm/min before IVF was a predictor of a negative outcome of IVF (RR = 1.41; 95% CI 1.2 - 1.67; p <0.001) (Balandina A.N. et al., 2019). Two studies did not evaluate the relationship between the TD test parameters and the hemostatic system with at least one final outcome.

CONCLUSIONS

: The results of this systematic review can be used to estimate the cost-effectiveness of TD for predicting VTEC in the postoperative period or the success of IVF.