Increasingly healthcare decision makers are simultaneously looking for efficiency and a more comprehensive evidence base. Real-world evidence (RWE) is the spotlight as a viable solution to these challenges. We are forming a new RWE SIG dedicated to increasing awareness, understanding, rigor and utilization of RWE as an important part of the wider evidence base for healthcare decision making. In order to be successful, ISPOR needs you, its members, to support this initiative. This open SIG meeting will present a range of RWE-specific topics to ascertain which concerns require immediate action, whether ISPOR is best placed to contribute to the solution and to start defining how we collectively might address them. During the meeting, attendees will have the opportunity to contribute their perspectives, suggest alternative topics and volunteer to help advance the future SIG activities, including an initiative on research transparency and developing definitions for the ISPOR revised book of terms.