OBJECTIVES

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To validate a predictive value of Thrombolysis in Myocardial Infarction (TIMI) risk score in developing country elderly female patients in order to curtail mortality rates.

METHODS

: This was a retrospective analysis of elderly female patients diagnosed with STEMI who underwent primary PCI. Patient’s demographic details and elements of TIMI risk score including age, comorbid, Killip classification; weight, anterior MI and total ischemic time were extracted from hospital records. The primary outcome was in-hospital mortality and early mortality reported on telephonic follow-up.

RESULTS

: A total of 404 elderly (≥65 years) women were included, the mean TIMI score was 5.25 ± 1.45 with 40.3% (163) patients with had TIMI score > 5. Post-procedure in-hospital mortality rate was 6.4% (26) and it was found to be significantly associated with TIMI score with the mortality rate of 3.1% at the score of 0-4 which raised up to 34.6% at the score of 8. A follow-up of 16.43 ± 7.40 months was successfully conducted for 211 (55.8%) patients and the early mortality rate was 20.3% (43/212) and re-occurrence of MI was observed in 20.8% (44/212). Early mortality was found to be significantly associated with TIMI score with an early mortality rate of 5.6% at the score of 0-4 which raised up to 54.5% at the score of 8. The predictive value (AUC) of TIMI risk score for in-hospital and early mortality were 0.709 (95% CI 0.591 -0.827; p <0.001) and 0.689 (95% CI 0.608 - 0.770; p <0.001) respectively.

CONCLUSIONS

: Increased adverse outcomes are observed at higher TIMI risk score not only in the hospital but also during long term follow-up. Therefore, the prognostic TIMI risk score is a robust tool in predicting both in-hospital as well as early mortality in the elderly female in data from this developing country.