OBJECTIVES: To comprehend what is necessary for the integration of point-of-care tests (POCTs) in primary care, an overview of the actors involved in the core aspects of healthcare operations, , is required. Such an overview, or business model (BM), has been published for the Netherlands, where POCTs are frequently used. However, a BM is currently lacking for England, where POCT use is limited. This paper therefore aims to identify the BM applying to POCT integration at general practices (GPs) in England, and to compare it with the existing Dutch BM. METHODS: A literature review was performed to describe the BM, including the key actors involved in the daily management of general practices as well as all stakeholders involved in promoting and supporting the integration and use of these POCTs. Interviews with stakeholders will be conducted to map the current care delivery process in general practices in England. After each interview, the BM will be updated based on the individual participant’s responses. Follow-up interviews with all participating stakeholders will be conducted for in-depth validation. RESULTS: The process of POCT integration in England can be considered complex owing to the large number of different stakeholders involved in POCT as compared with the Dutch healthcare system. This complexity may contribute to the lack of understanding amongst stakeholders of who is responsible for the integration of innovation, and thereby explain the limited integration of POCTs. It is anticipated that more about these barriers will be learned during the validation interviews. CONCLUSIONS: The successful integration of POCTs demands transformation of diagnostic services across healthcare organizations. The identification of England’s BM will potentially help with improving POCT integration by providing an overview of the organizations that play a role in this integration and those that could be affected by it. Validation of the BM using interviews with stakeholders is required.