OBJECTIVES: Medication error is a preventable event that may lead to inappropriate medication use among patients. WHO revealed that more than fifty percent of medicines are sold, prescribed, dispensed, and administered inappropriately. There is paucity of evidence in Ghana highlighting cost saving interventions made by health care providers in medication errors. This study sought to document the burden of medication errors and its associated factors in public health facilities of the Eastern Region of Ghana.METHODS: One hundred and fifty (150) medication error forms, representing 10% each of submitted Medication error intervention forms from January to December 2018 by hospitals in the Eastern Region of Ghana were carefully selected and documented information indicating medication errors were reviewed and analyzed using SPSS vs 22. The financial costs of the medication errors and the interventions were estimated using the 2018 Ghana National Health Insurance Scheme Price list.RESULTS: The highest incidence (46.5%) of medication error occurred among 20 – 59years old patients. Medication errors among female were significantly higher (73%) than their male counterparts (27%). Patient’s aged 20 – 59 years with acute illness were significantly associated with prescription error (chi square = 29.288 and p-value = 0.004) and these included; incorrect dosage, incorrect frequency of administration, polypharmacy and drug-treatment mismatch contributing about two thirds (69.7%) of all prescription errors .An estimated cost of Ghc18,500.53 (USD 3,432.38) of errors was documented and Ghc16,921.89 (USD3,139.49) was saved after the intervention. The medical consequences of increased adverse effects and deaths associated with the identified errors were prevented.CONCLUSIONS: The study demonstrates significant cost savings intervention to medication error. This warrants further studies to explore the financial contribution of medication errors to health care budget in Ghana.