A Systematic Review of ACTIVE Vaccine Surveillance Studies: Focused on the Vaccine Safety Datalink
Author(s)
ABSTRACT WITHDRAWN
OBJECTIVES: Vaccine active surveillance system is important to detect potential adverse events after the introduction of the vaccine. We aim to review and categorize the published literature to describe the characteristics of the studies using the VSD database and to identify possible study in vaccine active surveillance system such as VSD. METHODS: We reviewed all publications from January 1994 to August 2019 of the lists on the VSD website, and searched Medline and EMBASE for using the keyword 'Vaccine Safety Datalink’, ‘VSD database’. Two reviewers independently reviewed the literature, and if they specify that they were focused on the vaccine, adverse events (AEs) following vaccination, vaccine preventable disease (VPD) or VSD database and they were conducted using VSD database. We divided the categories into four categories; 'Description’ was divided into the incidence, coverage, and pattern, and 'Analysis’ was divided into safety, effectiveness, and factor. ‘Methodology' were classified study design and statistical methodology, and in the case of ‘VSD database’ were classified into database construction, linkage, and validation. RESULTS: From 334 studies, a total of 206 studies were included. According to the type of studies, the majority was analytical study (n=138, 60%), including vaccine safety (n=125, 54.35%). Forty-five (19.57%) studies were classified into descriptive study such as incidence of diseases (n=21, 9.13%) and vaccine coverage (n=21, 9.13%). Others were categorized as methodological study (n=23, 10%) and study on VSD database (n=24, 10.43%). The number of published literatures by year was increased gradually, the most in 2014 (n=24, 11.54%). Compared to other studies, the number of studies for vaccine safety has increased, particularly since after 2009. Vaccine safety studies were focused mainly on influenza (n=54, 19.08%), followed by HBV (n=23, 8.13%), MMR (n=18, 6.36%). CONCLUSIONS: This review showed that various studies, including vaccine safety research, can be conducted in vaccine active surveillance systems such as VSD.
Conference/Value in Health Info
2020-09, ISPOR Asia Pacific 2020, Seoul, South Korea
Value in Health Regional, Volume 22S (September 2020)
Code
PIN39
Topic
Epidemiology & Public Health, Real World Data & Information Systems
Topic Subcategory
Distributed Data & Research Networks, Health & Insurance Records Systems, Safety & Pharmacoepidemiology
Disease
Vaccines