Incidence and Prevalence of Osteoporosis and Related Fractures in ASIA and the Pacific: A Systematic Review
Author(s)
Leung MY(1, Brind’Amour KA2, Tinker J3, Eisman JA4
1Amgen JAPAC, Hong Kong, Hong Kong, 2HealthWords Ltd., Augusta, GA, USA, 3Moon Rabbit, Singapore, Singapore, 4Garvan Institute of Medical Research, Sydney, Australia
OBJECTIVES: Osteoporosis and related fractures are of increasing concern in Asia and the Pacific (APAC), where populations are aging rapidly. Understanding their pervasiveness can help nations address current public health needs and plan for the future burden of poor bone health on their citizens and economies. We aimed to collect estimates of the incidence and prevalence of osteoporosis and related fractures in 27 APAC nations. METHODS: We searched PubMed, Google Scholar, JSTOR, ScienceDirect, the Cochrane Database of Systematic Reviews, and Osteoporosis and Sarcopenia, plus Google and osteoporosis websites, following Cochrane Review methods whenever feasible. Key search strings included search-engine-specific variations on (osteoporo* OR bone density OR bone loss OR fragility OR low-trauma) AND (inciden* OR prevalen* OR fracture* OR annual OR rate OR epidemiol*) AND ([country name]). Papers were eligible from 2009 onward if they included any estimate of osteoporosis (not disease- or drug-induced) or related fracture data for adult populations. RESULTS: The initial search yielded 72,435 publications, of which 465 met all inclusion criteria. No data were retrieved for Brunei, Cambodia, Maldives, Myanmar/Burma, or Tajikistan, and not all countries had data for all outcomes. Estimates were generally higher for women and increased with age. Adult population estimates of osteoporosis prevalence ranged from 3.1% of adults (Australia) to 51.4% (Taiwan). Osteoporotic hip fracture incidence per 100,000 adults aged 50+ ranged from 73 (Sri Lanka) to 729 (Taiwan). These ranges are susceptible to distortion due to outliers and poorly described populations, so data for multiple population and outcome subgroups were collected for each country. CONCLUSIONS: APAC countries have not escaped the problem of poor bone health. Data quality and generalizability varied, even within countries, and revealed substantially different results depending on study population, screening equipment, and T-score reference population. Tighter inclusion criteria and meta-analysis could improve the reliability of national estimates.
Conference/Value in Health Info
2020-09, ISPOR Asia Pacific 2020, Seoul, South Korea
Value in Health Regional, Volume 22S (September 2020)
Code
PMS6
Topic
Epidemiology & Public Health
Topic Subcategory
Public Health
Disease
Musculoskeletal Disorders