EPIDEMIOLOGICAL CHARACTERISTICS OF DIABETIC KIDNEY DISEASE IN CHINESE PATIENTS WITH TYPE 2 DIABETES VISITING A TERTIARY CARE HOSPITAL: A RETROSPECTIVE ANALYSIS
Author(s)
Wenbin Tang, PhD, MD1, Yang Luo, MD1, Ting Zhang, MD1, Liang Tan, MD2, Zhixin Zhang, MD2, Fang Liu, PhD, MD1, Li Yan, MD2, Wendong Chen, PhD, MD1;
1Xiangya Hospital, Central South University, Changsha, China, 2Changsha Normin Health Technology Ltd, Changsha, China
1Xiangya Hospital, Central South University, Changsha, China, 2Changsha Normin Health Technology Ltd, Changsha, China
OBJECTIVES: To estimate the prevalence and incidence of diabetic kidney disease (DKD) among patients with type 2 diabetes mellitus (T2DM) in a large tertiary hospital in China, and to evaluate the associations between modifiable metabolic risk factors and the risk of DKD, with particular focus on the impact of achieving glycaemic, blood pressure, and lipid targets.
METHODS: This retrospective cohort study included patients with T2DM who visited Xiangya Hospital between 2014 and 2024. Electronic medical records were used to identify DKD diagnoses, demographic characteristics, and metabolic indicators, including HbA1c, blood pressure, and LDL-C. Annual T2DM cohorts were constructed to estimate DKD prevalence. Patients without DKD at first visit were followed to assess incidence of DKD. Multivariable Cox regression was used to identify risk factors for DKD, and subgroup analyses evaluated the impact of target attainment for metabolic factors on the risk of DKD.
RESULTS: The annual prevalence of DKD ranged from 14.1% to 18.2% during 2014-2024. The cumulative incidence of DKD was 13.8% over a mean follow-up of 3.8 years. Higher mean HbA1c [Hazard ratio (HR) 1.153, 95% CI 1.094-1.215], diastolic blood pressure (HR 1.030, 95% CI 1.021-1.039), and LDL-C (HR 1.171, 95% CI 1.073-1.279) were independently associated with increased DKD risk. Achieving HbA1c targets alone (HR 0.699, p=0.002), HbA1c plus blood pressure targets (HR 0.193, p=0.001), or HbA1c plus LDL-C targets (HR 0.643, p=0.002) was significantly associated with lower DKD risk.
CONCLUSIONS: DKD remains a substantial burden among Chinese adults with T2DM. Integrated control of glycemia and blood pressure may substantially reduce the risk of DKD in Chinese patients with T2DM.
METHODS: This retrospective cohort study included patients with T2DM who visited Xiangya Hospital between 2014 and 2024. Electronic medical records were used to identify DKD diagnoses, demographic characteristics, and metabolic indicators, including HbA1c, blood pressure, and LDL-C. Annual T2DM cohorts were constructed to estimate DKD prevalence. Patients without DKD at first visit were followed to assess incidence of DKD. Multivariable Cox regression was used to identify risk factors for DKD, and subgroup analyses evaluated the impact of target attainment for metabolic factors on the risk of DKD.
RESULTS: The annual prevalence of DKD ranged from 14.1% to 18.2% during 2014-2024. The cumulative incidence of DKD was 13.8% over a mean follow-up of 3.8 years. Higher mean HbA1c [Hazard ratio (HR) 1.153, 95% CI 1.094-1.215], diastolic blood pressure (HR 1.030, 95% CI 1.021-1.039), and LDL-C (HR 1.171, 95% CI 1.073-1.279) were independently associated with increased DKD risk. Achieving HbA1c targets alone (HR 0.699, p=0.002), HbA1c plus blood pressure targets (HR 0.193, p=0.001), or HbA1c plus LDL-C targets (HR 0.643, p=0.002) was significantly associated with lower DKD risk.
CONCLUSIONS: DKD remains a substantial burden among Chinese adults with T2DM. Integrated control of glycemia and blood pressure may substantially reduce the risk of DKD in Chinese patients with T2DM.
Conference/Value in Health Info
2026-05, ISPOR 2026, Philadelphia, PA, USA
Value in Health, Volume 29, Issue S6
Code
EPH220
Topic
Epidemiology & Public Health
Disease
SDC: Diabetes/Endocrine/Metabolic Disorders (including obesity), SDC: Urinary/Kidney Disorders