DR. TAORAN LIU
Author(s)
Taoran Liu, PhD1, YANGYANG GAO, PhD1, Wai-kit Ming, PhD, MD, MPH, MMSc2;
1City University of Hong Kong, Department of Infectious Diseases and Public Health, Hong Kong, Hong Kong, 2City University of Hong Kong, Department of Infectious Diseases and Public Health, City University of Hong Kong, Hong Kong
1City University of Hong Kong, Department of Infectious Diseases and Public Health, Hong Kong, Hong Kong, 2City University of Hong Kong, Department of Infectious Diseases and Public Health, City University of Hong Kong, Hong Kong
OBJECTIVES: Recent measles outbreaks emphasize the importance of ensuring a high level of childhood vaccination coverage. This study aims to quantify how different vaccine attributes were preferred and whether perceived disease severity affects parents' preferences.
METHODS: We conducted a cross-sectional discrete choice experiment (DCE) across 17 countries. Five attributes were included: vaccine efficacy, risk of mild side effects, number of doses, manufacturer, and out-of-pocket cost. Respondents were required to complete task choices under two different disease-risk scenarios: 5% mortality rate and 50% mortality rate. Multinomial logit models were applied to estimate respondents' part-worth utilities and willingness to pay (WTP).
RESULTS: A total of 1062 respondents participated; nearly half were aged 25-34, and 73 % held a bachelor’s degree or higher. Vaccine efficacy was presented to be the most important attribute for respondents, with a higher weighted importance under the 50% mortality rate scenario. The number of doses was ranked as the least important attribute under scenarios with a 5% mortality rate, while the risk of side effects was the least important attribute under scenarios with a 50% mortality rate. Parents were willing to pay US$234 under low mortality scenarios and US$271 under high risk to increase efficacy from 70 % to 100 %. In addition, respondents were willing to pay US$173 more against Chinese vaccines. Moreover, respondents were also willing to pay US$42-96 to reduce the mild side-effects risk from 20% to 1%, while a one-dose vaccine yielded approximately US$33 in low mortality rate scenarios but US$108 in a high mortality scenarios. Across all attributes, WTP increased under high mortality scenarios task choices.
CONCLUSIONS: Disease severity, as an equity factor, is also presented as an important factor in parents' trade-offs in their decision for childhood vaccinations. To improve the childhood vaccine uptake, policies should emphasise perceived disease severity, as well as vaccine benefits and transparent safety communication.
METHODS: We conducted a cross-sectional discrete choice experiment (DCE) across 17 countries. Five attributes were included: vaccine efficacy, risk of mild side effects, number of doses, manufacturer, and out-of-pocket cost. Respondents were required to complete task choices under two different disease-risk scenarios: 5% mortality rate and 50% mortality rate. Multinomial logit models were applied to estimate respondents' part-worth utilities and willingness to pay (WTP).
RESULTS: A total of 1062 respondents participated; nearly half were aged 25-34, and 73 % held a bachelor’s degree or higher. Vaccine efficacy was presented to be the most important attribute for respondents, with a higher weighted importance under the 50% mortality rate scenario. The number of doses was ranked as the least important attribute under scenarios with a 5% mortality rate, while the risk of side effects was the least important attribute under scenarios with a 50% mortality rate. Parents were willing to pay US$234 under low mortality scenarios and US$271 under high risk to increase efficacy from 70 % to 100 %. In addition, respondents were willing to pay US$173 more against Chinese vaccines. Moreover, respondents were also willing to pay US$42-96 to reduce the mild side-effects risk from 20% to 1%, while a one-dose vaccine yielded approximately US$33 in low mortality rate scenarios but US$108 in a high mortality scenarios. Across all attributes, WTP increased under high mortality scenarios task choices.
CONCLUSIONS: Disease severity, as an equity factor, is also presented as an important factor in parents' trade-offs in their decision for childhood vaccinations. To improve the childhood vaccine uptake, policies should emphasise perceived disease severity, as well as vaccine benefits and transparent safety communication.
Conference/Value in Health Info
2026-05, ISPOR 2026, Philadelphia, PA, USA
Value in Health, Volume 29, Issue S6
Code
PCR201
Topic
Patient-Centered Research
Topic Subcategory
Patient Engagement
Disease
SDC: Pediatrics, STA: Vaccines