COST EFFECTIVENESS ANALYSIS OF OBINUTUZUMAB? VERSUS CYCLOSPORINE A IN THE TREATMENT OF PRIMARY MEMBRANOUS NEPHROPATHY
Author(s)
Yimiao Zhang, M.Med.1, Mattias Kyhlstedt, .2, Baorong Yu, PhD3, Zhao Cui, M.D.1, Chunlu Wang, Doctor Candidate3.
1Renal Division, Peking University First Hospital, Beijing, China, 2Synergus RWE, Akersberga, Sweden, 3Center for Health Insurance & Health Services Research, The University of International Business and Economics, Beijing, China.
1Renal Division, Peking University First Hospital, Beijing, China, 2Synergus RWE, Akersberga, Sweden, 3Center for Health Insurance & Health Services Research, The University of International Business and Economics, Beijing, China.
OBJECTIVES: To evaluate the cost-effectiveness of Obinutuzumab β, a novel CD20-targeted monoclonal antibody, compared to Cyclosporine A (CsA) in the treatment of primary membranous nephropathy (PMN) from a Chinese healthcare perspective.
METHODS: A Markov model was designed for a 51-year-old male patient with PMN treating by Obinutuzumab β and CsA, and projected outcomes over a lifetime horizon. Health states included in the model were complete remission (CR), partial remission (PR), active disease, relapse, end-stage renal disease (including haemo- or peritoneal dialysis and renal transplant), and death. Effectiveness data were obtained from Phase III clinical trials. Costs included drug acquisition, administration, management of adverse events and following treatments. The primary outcome was the incremental cost-effectiveness ratio (ICER), calculated as the incremental cost per quality-adjusted life year (QALY) gained. Deterministic and probabilistic sensitivity analyses were conducted.
RESULTS: Results:
At 12 months, Obinutuzumab β demonstrated a higher probability of achieving CR (37.7%) and PR (41.5%) compared to CsA (CR: 6.6%, PR: 10.5%). Over 18 months, Obinutuzumab β maintained superior efficacy with CR rates of 49.4% and PR rates of 35.0%, while CsA showed CR rates of 3.9% and PR rates of 11.9%. From a lifetime perspective, the treatment group receiving Obinutuzumab β incurred costs that were ¥132,100.23 lower than those of the Cyclosporine A treatment group. Additionally, the health outcomes were significantly improved, with an increase of 2.59 QALYs in the Obinutuzumab β group. Sensitivity analyses indicate that the most influential parameters affecting the results were the drug prices of the two treatment regimens and the proportions of patients achieving CR, PR, and relapse after treatment.
CONCLUSIONS: Obinutuzumab β offers improved efficacy and cost savings for PMN compared to CsA. Given the high unmet need in PMN management and the economic burden of current therapies, Obinutuzumab β represents a valuable addition to the treatment landscape.
METHODS: A Markov model was designed for a 51-year-old male patient with PMN treating by Obinutuzumab β and CsA, and projected outcomes over a lifetime horizon. Health states included in the model were complete remission (CR), partial remission (PR), active disease, relapse, end-stage renal disease (including haemo- or peritoneal dialysis and renal transplant), and death. Effectiveness data were obtained from Phase III clinical trials. Costs included drug acquisition, administration, management of adverse events and following treatments. The primary outcome was the incremental cost-effectiveness ratio (ICER), calculated as the incremental cost per quality-adjusted life year (QALY) gained. Deterministic and probabilistic sensitivity analyses were conducted.
RESULTS: Results:
At 12 months, Obinutuzumab β demonstrated a higher probability of achieving CR (37.7%) and PR (41.5%) compared to CsA (CR: 6.6%, PR: 10.5%). Over 18 months, Obinutuzumab β maintained superior efficacy with CR rates of 49.4% and PR rates of 35.0%, while CsA showed CR rates of 3.9% and PR rates of 11.9%. From a lifetime perspective, the treatment group receiving Obinutuzumab β incurred costs that were ¥132,100.23 lower than those of the Cyclosporine A treatment group. Additionally, the health outcomes were significantly improved, with an increase of 2.59 QALYs in the Obinutuzumab β group. Sensitivity analyses indicate that the most influential parameters affecting the results were the drug prices of the two treatment regimens and the proportions of patients achieving CR, PR, and relapse after treatment.
CONCLUSIONS: Obinutuzumab β offers improved efficacy and cost savings for PMN compared to CsA. Given the high unmet need in PMN management and the economic burden of current therapies, Obinutuzumab β represents a valuable addition to the treatment landscape.
Conference/Value in Health Info
2026-05, ISPOR 2026, Philadelphia, PA, USA
Value in Health, Volume 29, Issue S6
Code
EE509
Topic
Economic Evaluation
Disease
SDC: Urinary/Kidney Disorders