HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH LOWER-RISK MYELODYSPLASTIC SYNDROMES: EVIDENCE FROM A NATIONAL SURVEY IN CHINA
Author(s)
Yanan You, Doctor1, Yueyue Liu, Master1, Jingrong Zhu, Master1, Ziyan Xue, Master1, Xinran Han, Master1, Kewei Hu, Master1, Yufeng Jiang, Master1, Xingzhi Wang, Doctor2, Xin Wang, Doctor3, Xiaoyu Xi, Doctor1;
1China Pharmaceutical University, Nanjing, China, 2Bristol-Myers Squibb (China)Investment Co.,Ltd, Shanghai, China, 3Hangzhou Medical College, Hangzhou, China
1China Pharmaceutical University, Nanjing, China, 2Bristol-Myers Squibb (China)Investment Co.,Ltd, Shanghai, China, 3Hangzhou Medical College, Hangzhou, China
OBJECTIVES: Ineffective hematopoiesis and refractory cytopenia in lower-risk myelodysplastic syndromes (LR-MDS), cause impairment of mobility and self-care, negatively impacting patients’ prognosis and quality of life. Given the scarcity of LR-MDS patients’ health-utility values, this cross-sectional study aimed to quantify the health-related quality of life (HRQoL) in LR-MDS patients and explored its influencing factors.
METHODS: EQ-5D-5L was used to assess patients’ HRQoL. A convenience sampling strategy was employed to survey patients from the hematology departments of nine representative tertiary hospitals across China. A Tobit regression model was utilized to analyze the factors influencing HRQoL.
RESULTS: A total of 136 patients were recruited from 16 provinces. The mean age of the participants was 63.26±13.38 years, with 57.35% being male. Most patients reported low income, with 91.2% earning less than per capita GDP (￥95,749/$13,300) annually. 54.4% of patients had a history of blood transfusions. Problem frequency varied across the five dimensions, with daily activities most affected, followed by anxiety/depression, mobility, pain/discomfort, and self-care. Functional impairment in usual activities was reported as most severe (5.88% of patients reported grade 5 difficulty). Based on the Chinese EQ-5D-5L utility scoring system, the health utility value for Chinese LR-MDS patients was 0.803±0.220. Tobit regression analysis revealed that patients with the MDS with low blasts (MDS-LB)(β=0.114, p=0.003) and those with higher annual personal incomes (β=0.174, p=0.032) had higher health utility values. Conversely, a history of blood transfusions (β=−0.097, p=0.006) and being male (β=−0.076, p=0.033) were associated with lower health utility values.
CONCLUSIONS: Health utility of LR-MDS patients was significantly lower than the norm for the Chinese population (value of 0.946). HRQoL was markedly affected by both disease characteristics and socioeconomic factors. These results provide robust, disease-specific evidence to guide interventions aimed at improving HRQoL in LR-MDS patients and offer essential data to support future health technology assessments.
METHODS: EQ-5D-5L was used to assess patients’ HRQoL. A convenience sampling strategy was employed to survey patients from the hematology departments of nine representative tertiary hospitals across China. A Tobit regression model was utilized to analyze the factors influencing HRQoL.
RESULTS: A total of 136 patients were recruited from 16 provinces. The mean age of the participants was 63.26±13.38 years, with 57.35% being male. Most patients reported low income, with 91.2% earning less than per capita GDP (￥95,749/$13,300) annually. 54.4% of patients had a history of blood transfusions. Problem frequency varied across the five dimensions, with daily activities most affected, followed by anxiety/depression, mobility, pain/discomfort, and self-care. Functional impairment in usual activities was reported as most severe (5.88% of patients reported grade 5 difficulty). Based on the Chinese EQ-5D-5L utility scoring system, the health utility value for Chinese LR-MDS patients was 0.803±0.220. Tobit regression analysis revealed that patients with the MDS with low blasts (MDS-LB)(β=0.114, p=0.003) and those with higher annual personal incomes (β=0.174, p=0.032) had higher health utility values. Conversely, a history of blood transfusions (β=−0.097, p=0.006) and being male (β=−0.076, p=0.033) were associated with lower health utility values.
CONCLUSIONS: Health utility of LR-MDS patients was significantly lower than the norm for the Chinese population (value of 0.946). HRQoL was markedly affected by both disease characteristics and socioeconomic factors. These results provide robust, disease-specific evidence to guide interventions aimed at improving HRQoL in LR-MDS patients and offer essential data to support future health technology assessments.
Conference/Value in Health Info
2026-05, ISPOR 2026, Philadelphia, PA, USA
Value in Health, Volume 29, Issue S6
Code
PCR140
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
SDC: Oncology