EVALUATION AND VALIDATION OF A NOVEL POISON SEVERITY AND MORTALITY SCALE: A PILOT STUDY
Author(s)
RIYA SINGHAL, PharmD1, Crispin D. J, PharmD2, Sannidhi Prabhu, PharmD2, Adusumilli Pramod Kumar, PHD3;
1M S Ramaiah University Of Applied Sciences, Student, Bengaluru, India, 2M S Ramaiah University Of Applied Sciences, Bengaluru, India, 3M S Ramaiah University Of Applied Sciences, Bangalore, India
1M S Ramaiah University Of Applied Sciences, Student, Bengaluru, India, 2M S Ramaiah University Of Applied Sciences, Bengaluru, India, 3M S Ramaiah University Of Applied Sciences, Bangalore, India
OBJECTIVES: Poisoning remains a major health issue, especially in developing countries, contributing to high emergency admissions and mortality. This pilot study aims to validate an enhanced clinical scale for poisoning cases to improve risk stratification, triage efficiency, and clinical outcomes in emergency settings.
METHODS: An ambispective study was carried out in a tertiary care hospital included patients with confirmed poisoning. The novel scale was developed through a standardized methodology and stratified according to toxidromic classifications. Data were collected using structured forms, and each case was assessed using the new severity and mortality scale. Scores were compared with PSS and APACHE IV. Statistical analysis included Kruskal-Wallis, Post Hoc, Receiver operating characteristic or AUC and Cronbach’s alpha to evaluate validity and internal consistency.
RESULTS: In this study, organophosphorus compounds were the most common poison (36.7%), followed by corrosives (20%) and rodenticides (16.7%). The newly developed Poison Severity and Mortality Scale, pilot-tested on 30 patients, showed excellent internal consistency (Cronbach’s alpha = 0.894). Kruskal-Wallis tests revealed significant differences in severity using PSS (H=28.00, p= 0.00), and the novel scale (H=9.594, p=0.008). Mortality prediction was also significant APACHE IV (H=19.955, p=0.00) and the novel scale (H=8.067, p=0.015).
CONCLUSIONS: The newly developed clinical scoring system, combining real-time severity and mortality prediction, showed comparable sensitivity and specificity to PSS and APACHE IV. It aligned well with actual outcomes in emergency settings, enhancing triage and clinical decisions. Further validation with a larger sample is planned to confirm its reliability and refine the scoring system.
METHODS: An ambispective study was carried out in a tertiary care hospital included patients with confirmed poisoning. The novel scale was developed through a standardized methodology and stratified according to toxidromic classifications. Data were collected using structured forms, and each case was assessed using the new severity and mortality scale. Scores were compared with PSS and APACHE IV. Statistical analysis included Kruskal-Wallis, Post Hoc, Receiver operating characteristic or AUC and Cronbach’s alpha to evaluate validity and internal consistency.
RESULTS: In this study, organophosphorus compounds were the most common poison (36.7%), followed by corrosives (20%) and rodenticides (16.7%). The newly developed Poison Severity and Mortality Scale, pilot-tested on 30 patients, showed excellent internal consistency (Cronbach’s alpha = 0.894). Kruskal-Wallis tests revealed significant differences in severity using PSS (H=28.00, p= 0.00), and the novel scale (H=9.594, p=0.008). Mortality prediction was also significant APACHE IV (H=19.955, p=0.00) and the novel scale (H=8.067, p=0.015).
CONCLUSIONS: The newly developed clinical scoring system, combining real-time severity and mortality prediction, showed comparable sensitivity and specificity to PSS and APACHE IV. It aligned well with actual outcomes in emergency settings, enhancing triage and clinical decisions. Further validation with a larger sample is planned to confirm its reliability and refine the scoring system.
Conference/Value in Health Info
2026-05, ISPOR 2026, Philadelphia, PA, USA
Value in Health, Volume 29, Issue S6
Code
EPH132
Topic
Epidemiology & Public Health
Topic Subcategory
Public Health
Disease
No Additional Disease & Conditions/Specialized Treatment Areas