COVERAGE COMPLETENESS AND TREATMENT COST ESTIMATION FOR ADMINISTERED DRUGS IN US COMMERCIAL PAYER PRICE TRANSPARENCY DATA

Author(s)

William P. Pajerowski, PhD1, Matthew Robben, BS2, Rafiq Ahmed, MBA3;
1Serif Health, Waban, MA, USA, 2Serif Health, Cincinnati, OH, USA, 3Serif Health, Los Angeles, CA, USA
OBJECTIVES: Payer Transparency-in-Coverage (TiC) machine-readable files (MRFs) include negotiated in-network rates that may support research and decision-making for administered drugs. Evidence on completeness for HCPCS “J” codes and consistency for NDC-referenced drug rates is limited. We evaluated code coverage, reporting patterns, and reimbursement variation relative to Medicare Part B ASP.
METHODS: Our organization ingested TiC MRFs from 234 U.S. commercial payers posted in December 2025 and extracted negotiated rates for administered drugs. HCPCS coverage was assessed against active Level II HCPCS J-codes from CMS reference files. Commercial reimbursement was benchmarked to Medicare Part B Average Sales Price (ASP) limits using Q4 2024 ASP reference files. Outcomes included: (1) code-level presence (any rate observed), (2) payer-level reporting (share of payers with ≥1 in-network rate per code), (3) median number of in-network provider organizations associated per administered drug code, (4) commercial-to-ASP differentials (negotiated rate as a percent of Medicare reimbursement), (5) estimation and summary of treatment episode and plan-level costs (PMPM).
RESULTS: TiC MRFs captured essentially all active J-codes (97% of 1,085 HCPCS Codes reviewed), and most payers reported at least one in-network rate for the majority of J-codes ([Median_%_Payers_Per_Code], IQR [IQR]). Negotiated reimbursement varied widely relative to ASP (median ratio [Median_Ratio], p10-p90 [P10_Ratio]-[P90_Ratio]), with outliers above [X]× ASP observed in specific payer and site-of-care segments ([Pct_Codes_Above_X_ASP]%). Availability of provider identifiers and billing class fields differed by payer and file structure ([NPI/EIN/Billing_Class Completeness Placeholder]).
CONCLUSIONS: TiC MRFs provide near-complete HCPCS J-code coverage and enable large-scale assessment of commercial reimbursement variation compared with Medicare Part B ASP. The observed dispersion in negotiated rates across payers and settings supports use cases in contracting intelligence, market access research, and real-world economic evaluation. Continued improvements in file consistency and identifier completeness would further strengthen cross-payer comparability.

Conference/Value in Health Info

2026-05, ISPOR 2026, Philadelphia, PA, USA

Value in Health, Volume 29, Issue S6

Code

RWD83

Topic

Real World Data & Information Systems

Disease

STA: Biologics & Biosimilars, STA: Generics, STA: Genetic, Regenerative & Curative Therapies, STA: Multiple/Other Specialized Treatments, STA: Vaccines

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