ASSESSING THE BURDEN OF HIDRADENITIS SUPPURATIVA AND THE INFLUENCE OF SOCIAL DETERMINANTS OF HEALTH ON PATIENT-REPORTED QUALITYOF LIFE
Author(s)
Ebuka I. Onyenobi, MS1, Godwin E. Okoye, MS, RPh2, Nkem Ekeruche, PharmD3;
1University of Maryland School of Medicine, Baltimore, MD, USA, 2University of Texas at Austin College of Pharmacy, AUSTIN, TX, USA, 3Precision AQ, New York, NY, USA
1University of Maryland School of Medicine, Baltimore, MD, USA, 2University of Texas at Austin College of Pharmacy, AUSTIN, TX, USA, 3Precision AQ, New York, NY, USA
OBJECTIVES: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition. The role of social determinants of health (SDOH) in shaping disease experience and quality of life (QoL) remains understudied. This study aimed to evaluate the impact of HS on patient reported QoL and to assess the influence of SDOH on QoL outcomes.
METHODS: Using data from the All of Us Research Program, patients with HS were matched to controls in a 1:2 ratio using propensity score matching based on age, sex, race, BMI, and smoking status. QoL was assessed using the PROMIS Global Health v1.2 short form, with physical and mental health measures converted to T-scores where higher scores indicated better QoL. Multivariable linear regression models were used to evaluate the association between HS and QoL in the full matched sample, as well as the association between SDOH factors and QoL among patients with HS only.
RESULTS: A total of 1,748 patients with HS were matched to 3,496 controls. HS was significantly associated with lower physical (β = -2.76) and mental (β = -2.11) QoL compared to matched controls (p < 0.001). Among patients with HS, several SDOH including, lower educational attainment (β = -6.81), unemployment (β = -9.09), low income (β = -9.08), Medicaid insurance coverage (β = -5.97), and housing insecurity (β = -3.65) were independently associated with lower physical QoL (p < 0.001). Mental health QoL demonstrated similar trends. Racial disparities were also observed with Hispanic (β = -2.59) and Black (β = -1.36) patients reporting significantly lower physical QoL than White patients (p < 0.001).
CONCLUSIONS: HS is associated with significant impairments in QoL that are further influenced by socioeconomic and racial disparities. Addressing these factors may be essential to improving outcomes and promoting health equity in the management of HS.
METHODS: Using data from the All of Us Research Program, patients with HS were matched to controls in a 1:2 ratio using propensity score matching based on age, sex, race, BMI, and smoking status. QoL was assessed using the PROMIS Global Health v1.2 short form, with physical and mental health measures converted to T-scores where higher scores indicated better QoL. Multivariable linear regression models were used to evaluate the association between HS and QoL in the full matched sample, as well as the association between SDOH factors and QoL among patients with HS only.
RESULTS: A total of 1,748 patients with HS were matched to 3,496 controls. HS was significantly associated with lower physical (β = -2.76) and mental (β = -2.11) QoL compared to matched controls (p < 0.001). Among patients with HS, several SDOH including, lower educational attainment (β = -6.81), unemployment (β = -9.09), low income (β = -9.08), Medicaid insurance coverage (β = -5.97), and housing insecurity (β = -3.65) were independently associated with lower physical QoL (p < 0.001). Mental health QoL demonstrated similar trends. Racial disparities were also observed with Hispanic (β = -2.59) and Black (β = -1.36) patients reporting significantly lower physical QoL than White patients (p < 0.001).
CONCLUSIONS: HS is associated with significant impairments in QoL that are further influenced by socioeconomic and racial disparities. Addressing these factors may be essential to improving outcomes and promoting health equity in the management of HS.
Conference/Value in Health Info
2026-05, ISPOR 2026, Philadelphia, PA, USA
Value in Health, Volume 29, Issue S6
Code
PCR102
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
SDC: Rare & Orphan Diseases, SDC: Systemic Disorders/Conditions (Anesthesia, Auto-Immune Disorders (n.e.c.), Hematological Disorders (non-oncologic), Pain)