A SYSTEMATIC REVIEW OF FINDINGS AND METHODS IN ECONOMIC EVALUATIONS OF DYADIC HEALTHCARE INTERVENTIONS
Author(s)
MUNTASIR RAHMAN, MS1, Mashiad Mostafa, MA2, Richard Sawatzky, Ph.D.3, David G. Whitehurst, PhD4;
1Simon Fraser University, Faculty of Health Sciences, Burnaby, BC, Canada, 2BC Cancer Research Centre, Vancouver, BC, Canada, 3Trinity Western University, Langley, BC, Canada, 4Simon Fraser University, Burnaby, BC, Canada
1Simon Fraser University, Faculty of Health Sciences, Burnaby, BC, Canada, 2BC Cancer Research Centre, Vancouver, BC, Canada, 3Trinity Western University, Langley, BC, Canada, 4Simon Fraser University, Burnaby, BC, Canada
OBJECTIVES: Health technology assessment agencies are increasingly acknowledging the importance of caregiver outcomes (costs and benefits) in economic evaluations. Such outcomes are pertinent in the context of dyadic interventions, where two individuals comprise the ‘unit of care’. Contextual challenges for the economic evaluation of dyadic interventions include the measurement, valuation and aggregation of such costs and outcomes, as well as associated equity considerations. This review explores the methods adopted in economic evaluations of dyadic healthcare interventions, providing insight into these challenges.
METHODS: Seven databases (MEDLINE, CINAHL, PsycINFO, Embase, EconLit, IHTA Database, NHS Economic Evaluation Database) were searched to identify published, peer-reviewed economic evaluations (January 1990-August 2025) of dyadic healthcare interventions. Data extraction focuses on sociodemographic characteristics; characteristics of the economic evaluation design (e.g., perspective, length of follow-up, comparators, time-horizon, etc.); costs/resources and outcomes considered, and associated valuation methods; sensitivity analyses; and measures of intervention effectiveness and cost-effectiveness.
RESULTS: Screening and extraction are ongoing, with 8,004 unique records identified initially. Data will be synthesized in thematic tables comparing cost-effectiveness metrics and methodological approaches across intervention clusters. Figures will visualize cost-effectiveness metrics across major clusters of dyadic interventions (e.g., by health condition). Key themes, patterns, and outliers in the extracted data will be highlighted. Reporting quality and methodological rigour will be assessed using the CHEERS 2022 statement and the CHEC list, respectively. These emerging results will facilitate the synthesis of methods from the included studies and enable comparisons of choices made by researchers. Findings will be interpreted in the context of existing literature and guidelines, highlighting implications for practice and policy.
CONCLUSIONS: By synthesizing methodological approaches and patterns of choices, this review will provide a valuable resource for researchers conducting economic evaluations of dyadic healthcare interventions, helping inform best practices.
METHODS: Seven databases (MEDLINE, CINAHL, PsycINFO, Embase, EconLit, IHTA Database, NHS Economic Evaluation Database) were searched to identify published, peer-reviewed economic evaluations (January 1990-August 2025) of dyadic healthcare interventions. Data extraction focuses on sociodemographic characteristics; characteristics of the economic evaluation design (e.g., perspective, length of follow-up, comparators, time-horizon, etc.); costs/resources and outcomes considered, and associated valuation methods; sensitivity analyses; and measures of intervention effectiveness and cost-effectiveness.
RESULTS: Screening and extraction are ongoing, with 8,004 unique records identified initially. Data will be synthesized in thematic tables comparing cost-effectiveness metrics and methodological approaches across intervention clusters. Figures will visualize cost-effectiveness metrics across major clusters of dyadic interventions (e.g., by health condition). Key themes, patterns, and outliers in the extracted data will be highlighted. Reporting quality and methodological rigour will be assessed using the CHEERS 2022 statement and the CHEC list, respectively. These emerging results will facilitate the synthesis of methods from the included studies and enable comparisons of choices made by researchers. Findings will be interpreted in the context of existing literature and guidelines, highlighting implications for practice and policy.
CONCLUSIONS: By synthesizing methodological approaches and patterns of choices, this review will provide a valuable resource for researchers conducting economic evaluations of dyadic healthcare interventions, helping inform best practices.
Conference/Value in Health Info
2026-05, ISPOR 2026, Philadelphia, PA, USA
Value in Health, Volume 29, Issue S6
Code
SA34
Topic
Study Approaches
Topic Subcategory
Literature Review & Synthesis
Disease
No Additional Disease & Conditions/Specialized Treatment Areas